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- W2266235508 endingPage "R28" @default.
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- W2266235508 abstract "Proper expression of the glucocorticoid receptor (GR) plays an essential role in the development of the lung. GR expression and signalling in the lung is manipulated by administration of synthetic glucocorticoids (Gcs) for the treatment of neonatal, childhood and adult lung diseases. In lung cancers, Gcs are also commonly used as co-treatment during chemotherapy. This review summarises the effect of Gc monotherapy and co-therapy on lung cancers in vitro , in mouse models of lung cancer, in xenograft, ex vivo and in vivo . The disparity between the effects of pre-clinical and in vivo Gc therapy is commented on in light of the recent discovery of GR as a novel tumour suppressor gene." @default.
- W2266235508 created "2016-06-24" @default.
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- W2266235508 creator A5024116780 @default.
- W2266235508 creator A5044198492 @default.
- W2266235508 date "2016-04-01" @default.
- W2266235508 modified "2023-10-14" @default.
- W2266235508 title "Glucocorticoid receptors in lung cancer: new perspectives" @default.
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- W2266235508 doi "https://doi.org/10.1530/joe-15-0496" @default.
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