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- W2266313009 abstract "Objectives. The purpose of this study was to explore the association between polymorphisms of the Cytochrome P450 (CYP1A1) and Glutathione S-transferase M1 genes and DNA-protein crosslinks (DPC) among medical waste incinerator (MWI) workers in Taiwan.Methods. The exposure group comprised 31 MWI workers from eight hospitals. We selected 31 healthy, age- and gender-matched subjects with no history of malignant tumor, medication that might induce mutation, or exposure to carcinogens to serve as the control group. No significant differences in demographic or behavioral characteristics, such as age, gender, cigarette smoking, betel nut chewing, and alcohol consumption were found between the exposure and control groups. CYP1A1 and GSTM1 polymorphisms were analyzed by PCR. DPC were determined by a sodium dodecyl sulfate (SDS) precipitation assay.Results. The frequency distributions of the homozygous variant of CYP1A1 Msp I (v/v) in the exposure and control groups were 51.6% and 58.1%, respectively; however, the difference was not significant. Yet, there was a significant difference between the exposure and control groups in the GSTM1 null genotype (41.9% vs 25.8%; OR = 1.4, p = 0.01). There was also a significant difference in DPC levels between both groups (1.5% vs 0.9%, p ＜ 0.01). Furthermore, no significant relationship was found between CYP1A1 and GSTM1 genotypes and DPC levels in either group. Multiple regression analysis revealed that exposure to medical waste incineration was the only significant factor which predicted the variance in DPC levels (R2 = 0.85, p ＜ 0.01).Conclusions. This study suggests that DPC is a sensitive biomarker of DNA damage in workers exposed to MWI hazards. No association between the CYP1A1 and GSTM1 genes and DPC was observed." @default.
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- W2266313009 date "2004-03-01" @default.
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- W2266313009 title "Influence of Genotypic Polymorphisms of the CYP1A1 and GSTM1 Genes on DNA-Protein Crosslinks (DPC) among Incinerator Workers in Hospitals in Taiwan" @default.
- W2266313009 doi "https://doi.org/10.6558/mtjm.2004.9(1).2" @default.
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