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• W2266500925 abstract "When analyzed from transformed cell lysates, pp60v-src, the product of the Rous sarcoma virus src gene, typically appears as a single polypeptide of 60,000 molecular weight, phosphorylated at two major sites, an amino-terminal region serine residue and carboxy-terminal region tyrosine residue. We describe here the identification of variant forms of pp60v-src present in transformed cell lysates that exhibited an altered electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gels. This change in migration appeared to be the result of some alteration in the amino-terminal portion of the molecule and paralleled the appearance of extensive amino-terminal region tyrosine phosphorylation on the pp60v-src molecule. These structural modifications were further correlated with a dramatic increase in the protein kinase-specific activity of pp60v-src. The detection of these variant forms of pp60v-src depended on the prior treatment of the transformed cell cultures with vanadium ions or the inclusion in the cell disruption buffer of Mg2+ or ATP-Mg2+. The implications is that modified, highly active forms of the pp60v-src protein exist in transformed cells, but are transient and rapidly converted to stable forms, possibly by specific dephosphorylation. We suggest that amino-terminal region tyrosine phosphorylation of pp60v-src, presumably the result of autophosphorylation, serves to greatly enhance src protein enzymatic activity, but that much of the regulation of this transforming protein's function may involve a phosphotyrosyl protein phosphatase." @default.
• W2266500925 created "2016-06-24" @default.
• W2266500925 creator A5053206262 @default.
• W2266500925 creator A5087920067 @default.
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• W2266500925 date "1984-07-01" @default.
• W2266500925 modified "2023-09-26" @default.
• W2266500925 title "Structurally and functionally modified forms of pp60v-src in Rous sarcoma virus-transformed cell lysates" @default.
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• W2266500925 doi "https://doi.org/10.1128/mcb.4.7.1213-1220.1984" @default.
• W2266500925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/368901" @default.
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