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• W2266536744 abstract "A single copper(II)-catalyzed three-component cascade aminomethylation/cycloisomerization of propiolates to form imidazo[1,2-a]pyridines was explored. A straightforward method was developed for the practical synthesis of functionalized imidazo[1,2-a]pyridines from benzaldehydes, 2-aminopyridines, and propiolate derivatives catalyzed by Cu(OAc)2 hydrate in the presence of air. The protocol is marked by excellent yields, functional group tolerance, and, above all, adaptability to synthesize imidazo[1,2-a]pyridine-based drug molecules such as Alpidem." @default.
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• W2266536744 date "2015-10-21" @default.
• W2266536744 modified "2023-10-16" @default.
• W2266536744 title "Copper(II)-Mediated Aerobic Synthesis of Imidazo[1,2-<i>a</i>]pyridines via Cascade Aminomethylation/Cycloisomerization of Alkynes" @default.
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• W2266536744 doi "https://doi.org/10.1021/acs.joc.5b02102" @default.
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