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- W2266707907 abstract "Rare cancers are a growing group as a result of reclassification of common cancers by molecular markers. There is therefore an increasing need to identify methods to assess interventions that are sufficiently robust to potentially affect clinical practice in this setting. Methods advocated for clinical trials in rare diseases are not necessarily applicable in rare cancers. This Series paper describes research methods that are relevant for rare cancers in relation to the range of incidence levels. Strategies that maximise recruitment, minimise sample size, or maximise the usefulness of the evidence could enable the application of conventional clinical trial design to rare cancer populations. Alternative designs that address specific challenges for rare cancers with the aim of potentially changing clinical practice include Bayesian designs, uncontrolled n-of-1 trials, and umbrella and basket trials. Pragmatic solutions must be sought to enable some level of evidence-based health care for patients with rare cancers." @default.
- W2266707907 created "2016-06-24" @default.
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- W2266707907 date "2016-02-01" @default.
- W2266707907 modified "2023-09-23" @default.
- W2266707907 title "Research methods to change clinical practice for patients with rare cancers" @default.
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- W2266707907 doi "https://doi.org/10.1016/s1470-2045(15)00396-4" @default.
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