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- W2266745237 endingPage "a021386" @default.
- W2266745237 startingPage "a021386" @default.
- W2266745237 abstract "Hallmarks of the hepadnavirus replication cycle are the formation of covalently closed circular DNA (cccDNA) and the reverse transcription of a pregenomic RNA (pgRNA) in core particles leading to synthesis of the relaxed circular DNA (rcDNA) genome. cccDNA, the template for viral RNA transcription, is the basis for the persistence of these viruses in infected hepatocytes. In this review, we summarize the current state of knowledge on the mechanisms of hepadnavirus reverse transcription and the biochemical and structural properties of the viral reverse transcriptase (RT). We highlight important gaps in knowledge regarding cccDNA biosynthesis and stability. In addition, we discuss the impact of current antiviral therapies on viral persistence, particularly on cccDNA." @default.
- W2266745237 created "2016-06-24" @default.
- W2266745237 creator A5011350761 @default.
- W2266745237 creator A5057184332 @default.
- W2266745237 date "2015-07-01" @default.
- W2266745237 modified "2023-10-12" @default.
- W2266745237 title "Hepadnavirus Genome Replication and Persistence" @default.
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