Matches in SemOpenAlex for { <https://semopenalex.org/work/W2266898375> ?p ?o ?g. }
- W2266898375 endingPage "13" @default.
- W2266898375 startingPage "2" @default.
- W2266898375 abstract "The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that their immunomodulatory effects are able to suppress inflammatory responses, particularly in the privilege sites such as CNS and eyes. Kaposi's sarcoma-associated herpesvirus (KSHV), encodes a wide variety of immunoregulatory proteins which play central roles in modulating inflammatory and anti-inflammatory responses in favour of virus dissemination. One such protein is a homologue of the, encoded by open reading frame (ORF) K14 and therefore called vOX2. Based on its gene expression profile during the KSHV life cycle, it is hypothesised that vOX2 modulates host inflammatory responses. Moreover, it seems that vOX2 involves in cell adhesion and modulates innate immunity and promotes Th2 immune responses. In this review the activities of mammalian CD200 and KSHV CD200 in cell adhesion and immune system modulation are reviewed in the context of potential therapeutic agents." @default.
- W2266898375 created "2016-06-24" @default.
- W2266898375 creator A5000231575 @default.
- W2266898375 creator A5005941262 @default.
- W2266898375 creator A5059363999 @default.
- W2266898375 creator A5074510894 @default.
- W2266898375 date "2016-01-01" @default.
- W2266898375 modified "2023-09-27" @default.
- W2266898375 title "A new insight into viral proteins as Immunomodulatory therapeutic agents: KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein." @default.
- W2266898375 cites W143080318 @default.
- W2266898375 cites W1500591297 @default.
- W2266898375 cites W1502366909 @default.
- W2266898375 cites W1532718890 @default.
- W2266898375 cites W1534625428 @default.
- W2266898375 cites W1544498203 @default.
- W2266898375 cites W1563584966 @default.
- W2266898375 cites W1571985114 @default.
- W2266898375 cites W174470967 @default.
- W2266898375 cites W1758502430 @default.
- W2266898375 cites W1963987860 @default.
- W2266898375 cites W1970949598 @default.
- W2266898375 cites W1973927899 @default.
- W2266898375 cites W1974077164 @default.
- W2266898375 cites W1975831016 @default.
- W2266898375 cites W1978046735 @default.
- W2266898375 cites W1978921530 @default.
- W2266898375 cites W1979871839 @default.
- W2266898375 cites W1982397291 @default.
- W2266898375 cites W1985543678 @default.
- W2266898375 cites W1986705594 @default.
- W2266898375 cites W1990886828 @default.
- W2266898375 cites W1993748281 @default.
- W2266898375 cites W1993967286 @default.
- W2266898375 cites W1994885883 @default.
- W2266898375 cites W1995168398 @default.
- W2266898375 cites W1996197002 @default.
- W2266898375 cites W1997713315 @default.
- W2266898375 cites W1998226774 @default.
- W2266898375 cites W2006285478 @default.
- W2266898375 cites W2007639993 @default.
- W2266898375 cites W2008554619 @default.
- W2266898375 cites W2009448327 @default.
- W2266898375 cites W2009588083 @default.
- W2266898375 cites W2010279858 @default.
- W2266898375 cites W2011182267 @default.
- W2266898375 cites W2012604818 @default.
- W2266898375 cites W2015050458 @default.
- W2266898375 cites W2015183783 @default.
- W2266898375 cites W2016212226 @default.
- W2266898375 cites W2017101778 @default.
- W2266898375 cites W2027249090 @default.
- W2266898375 cites W2032438721 @default.
- W2266898375 cites W2033271712 @default.
- W2266898375 cites W2033537883 @default.
- W2266898375 cites W2038888556 @default.
- W2266898375 cites W2041112741 @default.
- W2266898375 cites W2043236653 @default.
- W2266898375 cites W2043457317 @default.
- W2266898375 cites W2051587095 @default.
- W2266898375 cites W2053266533 @default.
- W2266898375 cites W2056326425 @default.
- W2266898375 cites W2059108822 @default.
- W2266898375 cites W2062340794 @default.
- W2266898375 cites W2062568672 @default.
- W2266898375 cites W2064176774 @default.
- W2266898375 cites W2065537276 @default.
- W2266898375 cites W2066257482 @default.
- W2266898375 cites W2066803165 @default.
- W2266898375 cites W2067488876 @default.
- W2266898375 cites W2068698671 @default.
- W2266898375 cites W2070224660 @default.
- W2266898375 cites W2071561368 @default.
- W2266898375 cites W2074487736 @default.
- W2266898375 cites W2081384923 @default.
- W2266898375 cites W2087785715 @default.
- W2266898375 cites W2091719796 @default.
- W2266898375 cites W2092156350 @default.
- W2266898375 cites W2095277848 @default.
- W2266898375 cites W2095659076 @default.
- W2266898375 cites W2097851380 @default.
- W2266898375 cites W2100678254 @default.
- W2266898375 cites W2105126763 @default.
- W2266898375 cites W2106634168 @default.
- W2266898375 cites W2112137240 @default.
- W2266898375 cites W2117367856 @default.
- W2266898375 cites W2119691626 @default.
- W2266898375 cites W2119814069 @default.
- W2266898375 cites W2121478123 @default.
- W2266898375 cites W2131966414 @default.
- W2266898375 cites W2136728678 @default.
- W2266898375 cites W2144720739 @default.
- W2266898375 cites W2150972461 @default.
- W2266898375 cites W2155725804 @default.
- W2266898375 cites W2158692057 @default.
- W2266898375 cites W2159163386 @default.
- W2266898375 cites W2159744102 @default.
- W2266898375 cites W2161899228 @default.
- W2266898375 cites W2164815203 @default.