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• W2266915341 abstract "OBJECTIVE: To determine the value of the Framingham Risk Score (FRS) for Prediction of Stroke within 10 Years among HIV+ men in the highly active antiretroviral treatment (HAART) era compared to HIV- men. BACKGROUND: The FRS for Stroke includes assessment of baseline vascular risk factors to predict the long term risk of stroke. The score was developed in an HIV-uninfected population and has not been tested for predictive accuracy in HIV+ men. DESIGN/METHODS: The Multi-Center AIDS Cohort Study is an ongoing, prospective study of HIV+ and HIV- men who have sex with men (MSM) in 4 U.S. cities. We ascertained all reported stroke events during a recent 15-year timeframe during the HAART era (July 1, 1996-June 30, 2011). Framingham predictive scores were calculated 10 years prior to stroke events. HIV+ and HIV- participants with strokes were compared for FRS points and predicted 10-year stroke risk. RESULTS: There were 3945 participants (1776 HIV+, 2083 HIV-) in MACS during the study timeframe, including 57 HIV+ and 37 HIV- participants with strokes. The predicted baseline risk of stroke within 10-years was higher among HIV- men compared to HIV+ men with strokes (mean 5.9% vs. 2.5% risk, p=0.029). In the entire cohort of HIV+ men who did not experience a stroke (median age at first visit during the HAART era 41 years), the median 10-year predicted risk of stroke was 4% (range 0-15%). In HIV- men, (median age 43), it was 4% (0-22%). CONCLUSIONS: FRS Prediction for Stroke was systematically different in HIV+ vs. HIV- men with stroke events, suggesting an insufficiency in the predictive value of the FRS for HIV+ men. Corrective measures, including points for HIV status, should be considered to modify the FRS for Stroke to inform the large number of HAART-treated individuals at long term risk of stroke events. Supported by: Dr. Mateen is supported by an HIV/AIDS priority grant from the Canadian Institutes of Health Research. Disclosure: Dr. Mateen has nothing to disclose. Dr. Post has nothing to disclose. Dr. Sacktor has nothing to disclose. Dr. Abraham has nothing to disclose. Dr. Smith has nothing to disclose. Dr. Becker has nothing to disclose. Dr. Martin has nothing to disclose. Dr. Detels has nothing to disclose. Dr. Phair has nothing to disclose. Dr. Shinohara has nothing to disclose." @default.
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• W2266915341 date "2013-02-12" @default.
• W2266915341 modified "2023-09-27" @default.
• W2266915341 title "Insufficiency of the Framingham Risk Score for Stroke Prediction in HIV-Infected Men: Long Term Follow Up in the Multi-Center AIDS Cohort Study (MACS) (S38.005)" @default.
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