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- W2266921405 abstract "The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target genes. Blimp-1 promoted the migration and adhesion of plasmablasts. It directly repressed genes encoding several transcription factors and Aicda (which encodes the cytidine deaminase AID) and thus silenced B cell-specific gene expression, antigen presentation and class-switch recombination in plasmablasts. It directly activated genes, which led to increased expression of the plasma cell regulator IRF4 and proteins involved in immunoglobulin secretion. Blimp-1 induced the transcription of immunoglobulin genes by controlling the 3' enhancers of the loci encoding the immunoglobulin heavy chain (Igh) and κ-light chain (Igk) and, furthermore, regulated the post-transcriptional expression switch from the membrane-bound form of the immunoglobulin heavy chain to its secreted form by activating Ell2 (which encodes the transcription-elongation factor ELL2). Notably, Blimp-1 recruited chromatin-remodeling and histone-modifying complexes to regulate its target genes. Hence, many essential functions of plasma cells are under the control of Blimp-1." @default.
- W2266921405 created "2016-06-24" @default.
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- W2266921405 date "2016-01-18" @default.
- W2266921405 modified "2023-10-16" @default.
- W2266921405 title "Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation" @default.
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- W2266921405 doi "https://doi.org/10.1038/ni.3349" @default.
- W2266921405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790184" @default.
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