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- W2267072039 abstract "Abstract Priming of the mucosal immune system during the postnatal period substantially influences host–microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis." @default.
- W2267072039 created "2016-06-24" @default.
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- W2267072039 date "2015-07-21" @default.
- W2267072039 modified "2023-10-16" @default.
- W2267072039 title "Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period" @default.
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- W2267072039 doi "https://doi.org/10.1038/ncomms8725" @default.
- W2267072039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4518322" @default.
- W2267072039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26195040" @default.
- W2267072039 hasPublicationYear "2015" @default.
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