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• W2267079468 abstract "In the present study we investigated the role of sodium butyrate (butyrate), and its more palatable derivative, the N-(1-carbamoyl-2-phenyl-ethyl) butyramide (FBA), in animal models of acute and chronic pain. We found that oral administrations of butyrate (10–200 mg/Kg) or equimolecular FBA (21.2–424 mg/Kg) reduced visceral pain in a dose- and time-dependent manner. Both drugs were also effective in the formalin test, showing an antinociceptive effect. This analgesic effect was blocked by glibenclamide, suggesting the involvement of ATP-dependent K+ channels. Moreover, following repeated administration butyrate (100–200 mg/Kg) and FBA (212–424 mg/Kg) retained their analgesic properties in a model of neuropathic pain, reducing mechanical and thermal hyperalgesia in the chronic constriction injury (CCI) model. The involvement of peroxisome proliferator-activated receptor (PPAR) -α and -γ for the analgesic effect of butyrate was also investigated by using PPAR-α null mice or the PPAR-γ antagonist GW9662. Western blot analysis, confirmed the role of peroxisome receptors in butyrate effects, evidencing the increase of PPAR-α and -γ expression, associated to the reduction of inflammatory markers (COX-2, iNOS, TNF-α and cFOS). In conclusion, we describe the role of butyrate-based drugs in pain, identifying different and converging non-genomic and genomic mechanisms of action, which cooperate in nociception maintenance." @default.
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• W2267079468 date "2016-01-01" @default.
• W2267079468 modified "2023-09-23" @default.
• W2267079468 title "Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice" @default.
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• W2267079468 doi "https://doi.org/10.1016/j.phrs.2015.11.026" @default.
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