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- W2267080217 abstract "S100A8 and S100A9 are cytoplasmic proteins expressed by phagocytes. High concentrations of these proteins have been correlated with various inflammatory conditions, including autoimmune diseases such as rheumatoid arthritis and Crohn’s disease, as well as autoinflammatory diseases. In the present study, we examined the effects of S100A8 and S100A9 on the secretion of cytokines and chemokines from PBMCs. S100A8 and S100A9 induced the secretion of cytokines such as IL-6, IL-8, and IL-1β. This secretion was associated with the activation and translocation of the transcription factor NF-κB. Inhibition studies using antisense RNA and the pharmacological agent BAY-117082 confirmed the involvement of NF-κB in IL-6, IL-8, and IL-1β secretion. S100A8- and S100A9-mediated activation of NF-κB, the NLR family, pyrin domain-containing 3 (NLRP3) protein, and pro-IL-1β expression was dependent on the generation of reactive oxygen species. This effect was synergistically enhanced by ATP, a known inflammasome activator. These results suggest that S100A8 and S100A9 enhance the inflammatory response by inducing cytokine secretion of PBMCs." @default.
- W2267080217 created "2016-06-24" @default.
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- W2267080217 date "2013-08-19" @default.
- W2267080217 modified "2023-10-16" @default.
- W2267080217 title "S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1" @default.
- W2267080217 cites W127313292 @default.
- W2267080217 cites W1568529372 @default.
- W2267080217 cites W1680053970 @default.
- W2267080217 cites W1756750202 @default.
- W2267080217 cites W1766651653 @default.
- W2267080217 cites W1774714795 @default.
- W2267080217 cites W1950981769 @default.
- W2267080217 cites W1967342482 @default.
- W2267080217 cites W1975032025 @default.
- W2267080217 cites W1978415870 @default.
- W2267080217 cites W1981109162 @default.
- W2267080217 cites W1983308621 @default.
- W2267080217 cites W1984544536 @default.
- W2267080217 cites W1986755404 @default.
- W2267080217 cites W1987535382 @default.
- W2267080217 cites W1993517541 @default.
- W2267080217 cites W1994013949 @default.
- W2267080217 cites W1997664110 @default.
- W2267080217 cites W1998696780 @default.
- W2267080217 cites W1999634145 @default.
- W2267080217 cites W2002175938 @default.
- W2267080217 cites W2003710928 @default.
- W2267080217 cites W2009614275 @default.
- W2267080217 cites W2009800174 @default.
- W2267080217 cites W2013494956 @default.
- W2267080217 cites W2013826174 @default.
- W2267080217 cites W2033236322 @default.
- W2267080217 cites W2047891751 @default.
- W2267080217 cites W2050449334 @default.
- W2267080217 cites W2052129051 @default.
- W2267080217 cites W2053135113 @default.
- W2267080217 cites W2054571187 @default.
- W2267080217 cites W2060191107 @default.
- W2267080217 cites W2062152303 @default.
- W2267080217 cites W2063391683 @default.
- W2267080217 cites W2063894714 @default.
- W2267080217 cites W2071675524 @default.
- W2267080217 cites W2071963896 @default.
- W2267080217 cites W2072013779 @default.
- W2267080217 cites W2077668651 @default.
- W2267080217 cites W2090859543 @default.
- W2267080217 cites W2097599737 @default.
- W2267080217 cites W2097901114 @default.
- W2267080217 cites W2097905333 @default.
- W2267080217 cites W2098504210 @default.
- W2267080217 cites W2098627309 @default.
- W2267080217 cites W2104475738 @default.
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- W2267080217 cites W2118403357 @default.
- W2267080217 cites W2118897660 @default.
- W2267080217 cites W2121343525 @default.
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- W2267080217 cites W2160889746 @default.
- W2267080217 cites W2161948498 @default.
- W2267080217 cites W2165275387 @default.
- W2267080217 cites W2166209782 @default.
- W2267080217 cites W2170128987 @default.
- W2267080217 cites W2171699699 @default.
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- W2267080217 doi "https://doi.org/10.1371/journal.pone.0072138" @default.
- W2267080217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3747084" @default.
- W2267080217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23977231" @default.
- W2267080217 hasPublicationYear "2013" @default.
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