Matches in SemOpenAlex for { <https://semopenalex.org/work/W2267108686> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2267108686 abstract "The recent exponential increase in the use of engineered nanoparticles (eNPs) means both greater intentional and unintentional exposure of eNPs to microbes. Intentional use includes the use of eNPs as biocides; unintentional exposure results from the fact that eNPs are included in a variety of commercial products (paints, sunscreens, cosmetics.) Many of these eNPs include heavy metals or metal oxides such as titanium dioxide, silver, gold, zinc and zinc oxide. The fact that early studies of the impact of metallic nanoparticles achieved approximately 90% lethality to Ag, Cu eNPs, suggests that genetic variants are already circulating in bacteria that can be co-opted to provide heavy metal eNP resistance. This project has utilized laboratory experimental evolution to evolve eNP resistance in the bacterium Escherichia coli (K12 MG1655 strain.). This is currently being validated by demonstrating the greater fitness of evolved strains versus ancestral strains in the presence of different sized and coated silver nanoparticles (10nm, 40nm, citrate-coated, PVP-coated) as well as phenotypic changes in the bacterial cell wall (as measured by Atomic Force Microscopy, AFM.). Finally, the bacterial genomes of the evolved and ancestral strains were resequenced. The genomic basis of this complex phenotype was determined. The practical application of such knowledge cannot be underestimated since nature is already evolving nanoparticle resistant bacteria. Thus knowledge of the nature of the physiological, morphological, and genomic mechanisms of resistance will be essential to deploy sustainable use of NPs as biocides, and to prevent unintentional environmental damage." @default.
- W2267108686 created "2016-06-24" @default.
- W2267108686 creator A5031009015 @default.
- W2267108686 date "2015-01-01" @default.
- W2267108686 modified "2023-09-23" @default.
- W2267108686 title "Experimental evolution of silver nanoparticle resistance in Escherichia coli" @default.
- W2267108686 hasPublicationYear "2015" @default.
- W2267108686 type Work @default.
- W2267108686 sameAs 2267108686 @default.
- W2267108686 citedByCount "0" @default.
- W2267108686 crossrefType "journal-article" @default.
- W2267108686 hasAuthorship W2267108686A5031009015 @default.
- W2267108686 hasConcept C104317684 @default.
- W2267108686 hasConcept C155672457 @default.
- W2267108686 hasConcept C171250308 @default.
- W2267108686 hasConcept C178790620 @default.
- W2267108686 hasConcept C185592680 @default.
- W2267108686 hasConcept C192562407 @default.
- W2267108686 hasConcept C197471484 @default.
- W2267108686 hasConcept C31499863 @default.
- W2267108686 hasConcept C523546767 @default.
- W2267108686 hasConcept C535196362 @default.
- W2267108686 hasConcept C54355233 @default.
- W2267108686 hasConcept C547475151 @default.
- W2267108686 hasConcept C86803240 @default.
- W2267108686 hasConcept C89423630 @default.
- W2267108686 hasConceptScore W2267108686C104317684 @default.
- W2267108686 hasConceptScore W2267108686C155672457 @default.
- W2267108686 hasConceptScore W2267108686C171250308 @default.
- W2267108686 hasConceptScore W2267108686C178790620 @default.
- W2267108686 hasConceptScore W2267108686C185592680 @default.
- W2267108686 hasConceptScore W2267108686C192562407 @default.
- W2267108686 hasConceptScore W2267108686C197471484 @default.
- W2267108686 hasConceptScore W2267108686C31499863 @default.
- W2267108686 hasConceptScore W2267108686C523546767 @default.
- W2267108686 hasConceptScore W2267108686C535196362 @default.
- W2267108686 hasConceptScore W2267108686C54355233 @default.
- W2267108686 hasConceptScore W2267108686C547475151 @default.
- W2267108686 hasConceptScore W2267108686C86803240 @default.
- W2267108686 hasConceptScore W2267108686C89423630 @default.
- W2267108686 hasLocation W22671086861 @default.
- W2267108686 hasOpenAccess W2267108686 @default.
- W2267108686 hasPrimaryLocation W22671086861 @default.
- W2267108686 hasRelatedWork W1762665957 @default.
- W2267108686 hasRelatedWork W1969181076 @default.
- W2267108686 hasRelatedWork W1973091898 @default.
- W2267108686 hasRelatedWork W1976007226 @default.
- W2267108686 hasRelatedWork W1987190257 @default.
- W2267108686 hasRelatedWork W2068150197 @default.
- W2267108686 hasRelatedWork W2103123819 @default.
- W2267108686 hasRelatedWork W2199172748 @default.
- W2267108686 hasRelatedWork W2333255425 @default.
- W2267108686 hasRelatedWork W2582918288 @default.
- W2267108686 hasRelatedWork W2767978449 @default.
- W2267108686 hasRelatedWork W2772995273 @default.
- W2267108686 hasRelatedWork W2795634977 @default.
- W2267108686 hasRelatedWork W2807092944 @default.
- W2267108686 hasRelatedWork W3004900886 @default.
- W2267108686 hasRelatedWork W3092185448 @default.
- W2267108686 hasRelatedWork W3107339046 @default.
- W2267108686 hasRelatedWork W3126025677 @default.
- W2267108686 hasRelatedWork W3187677643 @default.
- W2267108686 hasRelatedWork W2801232999 @default.
- W2267108686 isParatext "false" @default.
- W2267108686 isRetracted "false" @default.
- W2267108686 magId "2267108686" @default.
- W2267108686 workType "article" @default.