FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2267153940> ?p ?o ?g. }

• W2267153940 endingPage "16220" @default.
• W2267153940 startingPage "16213" @default.
• W2267153940 abstract "Angelman syndrome (AS) is a neurodevelopmental disorder associated with developmental delay, lack of speech, motor dysfunction, and epilepsy. In the majority of the patients, AS is caused by the deletion of small portions of maternal chromosome 15 harboring the UBE3A gene. This results in a lack of expression of the UBE3A gene because the paternal allele is genetically imprinted. The UBE3A gene encodes an enzyme termed ubiquitin ligase E3A (E6-AP) that targets proteins for degradation by the 26S proteasome. Because neurodegenerative disease and other neurodevelopmental disorders have been linked to oxidative stress, we asked whether mitochondrial reactive oxygen species (ROS) played a role in impaired synaptic plasticity and memory deficits exhibited by AS model mice. We discovered that AS mice have increased levels of superoxide in area CA1 of the hippocampus that is reduced by MitoQ 10-methanesuflonate (MitoQ), a mitochondria-specific antioxidant. In addition, we found that MitoQ rescued impairments in hippocampal synaptic plasticity and deficits in contextual fear memory exhibited by AS model mice. Our findings suggest that mitochondria-derived oxidative stress contributes to hippocampal pathophysiology in AS model mice and that targeting mitochondrial ROS pharmacologically could benefit individuals with AS.Oxidative stress has been hypothesized to contribute to the pathophysiology of neurodevelopmental disorders, including autism spectrum disorders and Angelman syndrome (AS). Herein, we report that AS model mice exhibit elevated levels of mitochondria-derived reactive oxygen species in pyramidal neurons in hippocampal area CA1. Moreover, we demonstrate that the administration of MitoQ (MitoQ 10-methanesuflonate), a mitochondria-specific antioxidant, to AS model mice normalizes synaptic plasticity and restores memory. Finally, our findings suggest that antioxidants that target the mitochondria could be used therapeutically to ameliorate synaptic and cognitive deficits in individuals with AS." @default.
• W2267153940 created "2016-06-24" @default.
• W2267153940 creator A5005601516 @default.
• W2267153940 creator A5031323537 @default.
• W2267153940 creator A5040458740 @default.
• W2267153940 creator A5051946404 @default.
• W2267153940 creator A5062511010 @default.
• W2267153940 creator A5071099009 @default.
• W2267153940 date "2015-12-09" @default.
• W2267153940 modified "2023-10-16" @default.
• W2267153940 title "Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice" @default.
• W2267153940 cites W1503832746 @default.
• W2267153940 cites W1512824421 @default.
• W2267153940 cites W1630447241 @default.
• W2267153940 cites W17013332 @default.
• W2267153940 cites W1784600579 @default.
• W2267153940 cites W1865646478 @default.
• W2267153940 cites W1905863734 @default.
• W2267153940 cites W1925799544 @default.
• W2267153940 cites W1944081590 @default.
• W2267153940 cites W1983532821 @default.
• W2267153940 cites W1988664434 @default.
• W2267153940 cites W1988834114 @default.
• W2267153940 cites W1992577657 @default.
• W2267153940 cites W1993940861 @default.
• W2267153940 cites W1995115442 @default.
• W2267153940 cites W1997611244 @default.
• W2267153940 cites W2017048113 @default.
• W2267153940 cites W2017107194 @default.
• W2267153940 cites W2020585998 @default.
• W2267153940 cites W2034991523 @default.
• W2267153940 cites W2036724509 @default.
• W2267153940 cites W2038383414 @default.
• W2267153940 cites W2041807010 @default.
• W2267153940 cites W2043701381 @default.
• W2267153940 cites W2043882061 @default.
• W2267153940 cites W2050357506 @default.
• W2267153940 cites W2050604139 @default.
• W2267153940 cites W2050897300 @default.
• W2267153940 cites W2066059769 @default.
• W2267153940 cites W2073185743 @default.
• W2267153940 cites W2075059777 @default.
• W2267153940 cites W2078265076 @default.
• W2267153940 cites W2093575302 @default.
• W2267153940 cites W2107522917 @default.
• W2267153940 cites W2116251041 @default.
• W2267153940 cites W2116283958 @default.
• W2267153940 cites W2124062214 @default.
• W2267153940 cites W2128294896 @default.
• W2267153940 cites W2137671503 @default.
• W2267153940 cites W2142679757 @default.
• W2267153940 cites W2143860178 @default.
• W2267153940 cites W2149631083 @default.
• W2267153940 cites W4247088117 @default.
• W2267153940 doi "https://doi.org/10.1523/jneurosci.2246-15.2015" @default.
• W2267153940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4682786" @default.
• W2267153940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26658871" @default.
• W2267153940 hasPublicationYear "2015" @default.
• W2267153940 type Work @default.
• W2267153940 sameAs 2267153940 @default.
• W2267153940 citedByCount "51" @default.
• W2267153940 countsByYear W22671539402016 @default.
• W2267153940 countsByYear W22671539402017 @default.
• W2267153940 countsByYear W22671539402018 @default.
• W2267153940 countsByYear W22671539402019 @default.
• W2267153940 countsByYear W22671539402020 @default.
• W2267153940 countsByYear W22671539402021 @default.
• W2267153940 countsByYear W22671539402022 @default.
• W2267153940 countsByYear W22671539402023 @default.
• W2267153940 crossrefType "journal-article" @default.
• W2267153940 hasAuthorship W2267153940A5005601516 @default.
• W2267153940 hasAuthorship W2267153940A5031323537 @default.
• W2267153940 hasAuthorship W2267153940A5040458740 @default.
• W2267153940 hasAuthorship W2267153940A5051946404 @default.
• W2267153940 hasAuthorship W2267153940A5062511010 @default.
• W2267153940 hasAuthorship W2267153940A5071099009 @default.
• W2267153940 hasBestOaLocation W22671539401 @default.
• W2267153940 hasConcept C104317684 @default.
• W2267153940 hasConcept C134018914 @default.
• W2267153940 hasConcept C134459356 @default.
• W2267153940 hasConcept C148762608 @default.
• W2267153940 hasConcept C169760540 @default.
• W2267153940 hasConcept C170493617 @default.
• W2267153940 hasConcept C25602115 @default.
• W2267153940 hasConcept C2776151105 @default.
• W2267153940 hasConcept C2777041782 @default.
• W2267153940 hasConcept C2778691456 @default.
• W2267153940 hasConcept C2779388368 @default.
• W2267153940 hasConcept C2781161787 @default.
• W2267153940 hasConcept C28859421 @default.
• W2267153940 hasConcept C48349386 @default.
• W2267153940 hasConcept C54355233 @default.
• W2267153940 hasConcept C86803240 @default.
• W2267153940 hasConcept C98229152 @default.
• W2267153940 hasConceptScore W2267153940C104317684 @default.
• W2267153940 hasConceptScore W2267153940C134018914 @default.
• W2267153940 hasConceptScore W2267153940C134459356 @default.
• W2267153940 hasConceptScore W2267153940C148762608 @default.

• next