Matches in SemOpenAlex for { <https://semopenalex.org/work/W2267156617> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2267156617 abstract "We evaluated the effect of angiotensin-(1-7) [Ang-(1-7)] ICV chronic infusion in baseline and baroreflex control of renal sympathetic nerve activity (RSNA) in DOCA-salt hypertensive rats. Sprague-Dawley rats were submitted to uninephrectomy (UNX) or DOCA-salt hypertension model (UNX + DOCA + saline). After 7 days, Ang-(1-7) ICV infusion (0.2 nmol/ 0.5 μl/ hour) or 0.9% sterile saline (0.5 μl/ hour) was initiated by osmotic mini-pumps for 14 days. On the 21th day, the animals were anaesthetized (urethane; i.p.) and baseline arterial pressure (MAP), heart rate (HR) and RSNA, and baroreflex control RSNA were evaluated. As expected, DOCA-salt treatment induced an increase in baseline MAP (122 ± 3 mmHg, n=4 vs 93 ± 2 mmHg, n=5, UNX), reduced baroreflex control of RSNA (1.33 ± 0.10 %ΔRSNA/ mmHg, n=4 vs 2.73 ± 0.29 %ΔRSNA/ mmHg, n=5, UNX), without any changes in baseline HR or RSNA (130 ± 17 spikes/sec, n=5 vs 118 ± 12 spikes/sec, n=4 UNX). Animals submitted to Ang-(1-7) ICV infusion presented a reduced MAP (conscious rats) and a greater baroreflex control of RSNA (2.24 ± 0.20 %ΔRSNA/ mmHg, n=4), without any significant in baseline RSNA (113 ± 10 spikes/sec, n=4). These results showed that central Ang-(1-7) modulates baroreflex control of RSNA in DOCA-salt rats, and suggest that chronic increase in Ang-(1-7) levels in the brain may attenuate high blood pressure, in part by improving baroreflex control of sympathetic activity." @default.
- W2267156617 created "2016-06-24" @default.
- W2267156617 creator A5005830899 @default.
- W2267156617 creator A5016389116 @default.
- W2267156617 creator A5047929307 @default.
- W2267156617 creator A5070926183 @default.
- W2267156617 creator A5087277690 @default.
- W2267156617 date "2009-04-01" @default.
- W2267156617 modified "2023-10-14" @default.
- W2267156617 title "ANGIOTENSIN‐(1‐7) ICV CHRONIC INFUSION IMPROVES BAROREFLEX CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN DOCA‐SALT HYPERTENSIVE RATS" @default.
- W2267156617 doi "https://doi.org/10.1096/fasebj.23.1_supplement.610.4" @default.
- W2267156617 hasPublicationYear "2009" @default.
- W2267156617 type Work @default.
- W2267156617 sameAs 2267156617 @default.
- W2267156617 citedByCount "0" @default.
- W2267156617 crossrefType "journal-article" @default.
- W2267156617 hasAuthorship W2267156617A5005830899 @default.
- W2267156617 hasAuthorship W2267156617A5016389116 @default.
- W2267156617 hasAuthorship W2267156617A5047929307 @default.
- W2267156617 hasAuthorship W2267156617A5070926183 @default.
- W2267156617 hasAuthorship W2267156617A5087277690 @default.
- W2267156617 hasConcept C126322002 @default.
- W2267156617 hasConcept C134018914 @default.
- W2267156617 hasConcept C191237925 @default.
- W2267156617 hasConcept C198710026 @default.
- W2267156617 hasConcept C2776452961 @default.
- W2267156617 hasConcept C2776533406 @default.
- W2267156617 hasConcept C2777397205 @default.
- W2267156617 hasConcept C2777953023 @default.
- W2267156617 hasConcept C2908929049 @default.
- W2267156617 hasConcept C42219234 @default.
- W2267156617 hasConcept C71924100 @default.
- W2267156617 hasConcept C84393581 @default.
- W2267156617 hasConceptScore W2267156617C126322002 @default.
- W2267156617 hasConceptScore W2267156617C134018914 @default.
- W2267156617 hasConceptScore W2267156617C191237925 @default.
- W2267156617 hasConceptScore W2267156617C198710026 @default.
- W2267156617 hasConceptScore W2267156617C2776452961 @default.
- W2267156617 hasConceptScore W2267156617C2776533406 @default.
- W2267156617 hasConceptScore W2267156617C2777397205 @default.
- W2267156617 hasConceptScore W2267156617C2777953023 @default.
- W2267156617 hasConceptScore W2267156617C2908929049 @default.
- W2267156617 hasConceptScore W2267156617C42219234 @default.
- W2267156617 hasConceptScore W2267156617C71924100 @default.
- W2267156617 hasConceptScore W2267156617C84393581 @default.
- W2267156617 hasIssue "S1" @default.
- W2267156617 hasLocation W22671566171 @default.
- W2267156617 hasOpenAccess W2267156617 @default.
- W2267156617 hasPrimaryLocation W22671566171 @default.
- W2267156617 hasRelatedWork W1989753381 @default.
- W2267156617 hasRelatedWork W1992220075 @default.
- W2267156617 hasRelatedWork W2024736606 @default.
- W2267156617 hasRelatedWork W2042660006 @default.
- W2267156617 hasRelatedWork W2077998387 @default.
- W2267156617 hasRelatedWork W2126797993 @default.
- W2267156617 hasRelatedWork W2149410839 @default.
- W2267156617 hasRelatedWork W2151139437 @default.
- W2267156617 hasRelatedWork W2190649397 @default.
- W2267156617 hasRelatedWork W2744890335 @default.
- W2267156617 hasVolume "23" @default.
- W2267156617 isParatext "false" @default.
- W2267156617 isRetracted "false" @default.
- W2267156617 magId "2267156617" @default.
- W2267156617 workType "article" @default.