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- W2267244428 abstract "Herpesvirus saimiri (HVS) consistently induced lymphomas or lymphocytic leukemias in marmosets, Saguinus oedipus, S. nigricollis, and S. fuscicollis, but induced no disease in galagos, Galago crassicaudatus. Lymphoreticular proliferation was present at intramuscular inoculation sites and in nearly all lymphoid tissues as early as 10 days after inoculation. The disease was always fatal, but the course, never longer than 35 days in S. oedipus, was prolonged up to 116 days in S. fuscicollis. Inclusion bodies, viral particles, or virus-associated antigens were not detected in fresh neoplastic tissues or in circulating neoplastic cells, but the HVS genome was demonstrated in these tissues by consistent recovery of HVS after they were cultured in vitro. Virus was recoverable from the circulating leukocytes 2–6 weeks after inoculation, which was the interval when fluorescing and neutralizing antibodies were first detected in the serum. Horizontal transmission to contact-exposed cagemates was not observe." @default.
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- W2267244428 date "1971-11-01" @default.
- W2267244428 modified "2023-10-02" @default.
- W2267244428 title "Oncogenicity of <italic>Herpesvirus saimiri</italic> Marmoset Monkeys<xref ref-type=fn rid=FN1>2</xref>" @default.
- W2267244428 doi "https://doi.org/10.1093/jnci/47.5.1145" @default.
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