Matches in SemOpenAlex for { <https://semopenalex.org/work/W2267352598> ?p ?o ?g. }
- W2267352598 endingPage "60" @default.
- W2267352598 startingPage "47" @default.
- W2267352598 abstract "Gamma-hydroxybutyrate (GHB) is a putative neurotransmitter, a drug of abuse, and a medical treatment for narcolepsy and other neuropsychiatric disorders. Its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are endogenously converted to GHB and thereby exert their psychobehavioural effects. In humans, GHB has a wide spectrum of properties ranging from stimulation and euphoria in lower doses, to sedation, deep sleep, and coma after ingestion of high doses. However, behavioural studies in healthy volunteers remain scarce and are usually limited to psychomotor performance testing. Most available data arise from either qualitative studies with illicit users or clinical trials examining therapeutic properties of GHB (then usually termed sodium oxybate). Here, we present an overview of the behavioural effects of GHB, GBL, and 1,4-BD in these three populations. GHB and its precursors strongly influence behaviours related to core human autonomic functions such as control of food intake, sexual behaviour, and sleep-wake regulation. These effects are instrumentalised by illicit users and clinically utilised in neuropsychiatric disorders such as narcolepsy, fibromyalgia, and binge-eating syndrome. Considering the industry withdrawal from psychopharmacology development, repurposing of drugs according to their behavioural and clinical profiles has gained increasing relevance. As such, GHB seems to be an attractive candidate as an experimental therapeutic in depression." @default.
- W2267352598 created "2016-06-24" @default.
- W2267352598 creator A5002125925 @default.
- W2267352598 creator A5045362944 @default.
- W2267352598 date "2016-09-01" @default.
- W2267352598 modified "2023-09-26" @default.
- W2267352598 title "The behavioural profile of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol in humans" @default.
- W2267352598 cites W1480251240 @default.
- W2267352598 cites W1500761406 @default.
- W2267352598 cites W1511078671 @default.
- W2267352598 cites W1519155525 @default.
- W2267352598 cites W1558808486 @default.
- W2267352598 cites W1561443084 @default.
- W2267352598 cites W1574785319 @default.
- W2267352598 cites W1596768844 @default.
- W2267352598 cites W1781609959 @default.
- W2267352598 cites W1846087019 @default.
- W2267352598 cites W1906321336 @default.
- W2267352598 cites W1920931666 @default.
- W2267352598 cites W193039664 @default.
- W2267352598 cites W1930702365 @default.
- W2267352598 cites W1965032302 @default.
- W2267352598 cites W1966762204 @default.
- W2267352598 cites W1969268715 @default.
- W2267352598 cites W1969740093 @default.
- W2267352598 cites W1970316977 @default.
- W2267352598 cites W1970527119 @default.
- W2267352598 cites W1971526468 @default.
- W2267352598 cites W1972156507 @default.
- W2267352598 cites W1972520989 @default.
- W2267352598 cites W1976483990 @default.
- W2267352598 cites W1977926040 @default.
- W2267352598 cites W1979035325 @default.
- W2267352598 cites W1980077716 @default.
- W2267352598 cites W1980115598 @default.
- W2267352598 cites W1982264926 @default.
- W2267352598 cites W1982421301 @default.
- W2267352598 cites W1983190977 @default.
- W2267352598 cites W1983983149 @default.
- W2267352598 cites W1986823657 @default.
- W2267352598 cites W1987057282 @default.
- W2267352598 cites W1988277699 @default.
- W2267352598 cites W1988391948 @default.
- W2267352598 cites W1988877053 @default.
- W2267352598 cites W1990724423 @default.
- W2267352598 cites W1992136901 @default.
- W2267352598 cites W1993068004 @default.
- W2267352598 cites W1993747975 @default.
- W2267352598 cites W1995308306 @default.
- W2267352598 cites W1997017221 @default.
- W2267352598 cites W1999383058 @default.
- W2267352598 cites W1999957047 @default.
- W2267352598 cites W2002169972 @default.
- W2267352598 cites W2002293846 @default.
- W2267352598 cites W2002666550 @default.
- W2267352598 cites W2002723292 @default.
- W2267352598 cites W2004092919 @default.
- W2267352598 cites W2005528588 @default.
- W2267352598 cites W2006144421 @default.
- W2267352598 cites W2007889607 @default.
- W2267352598 cites W2008579214 @default.
- W2267352598 cites W2010019881 @default.
- W2267352598 cites W2011262185 @default.
- W2267352598 cites W2012118094 @default.
- W2267352598 cites W2012390284 @default.
- W2267352598 cites W2013243209 @default.
- W2267352598 cites W2015808888 @default.
- W2267352598 cites W2016249649 @default.
- W2267352598 cites W2016310399 @default.
- W2267352598 cites W2016365444 @default.
- W2267352598 cites W2017026425 @default.
- W2267352598 cites W2017885420 @default.
- W2267352598 cites W2019110855 @default.
- W2267352598 cites W2021013804 @default.
- W2267352598 cites W2021524647 @default.
- W2267352598 cites W2021581084 @default.
- W2267352598 cites W2024059065 @default.
- W2267352598 cites W2024549697 @default.
- W2267352598 cites W2025222214 @default.
- W2267352598 cites W2030534461 @default.
- W2267352598 cites W2030832082 @default.
- W2267352598 cites W2032943446 @default.
- W2267352598 cites W2033499154 @default.
- W2267352598 cites W2034846141 @default.
- W2267352598 cites W2036298862 @default.
- W2267352598 cites W2036443117 @default.
- W2267352598 cites W2036993233 @default.
- W2267352598 cites W2037210395 @default.
- W2267352598 cites W2038702925 @default.
- W2267352598 cites W2039188295 @default.
- W2267352598 cites W2040273538 @default.
- W2267352598 cites W2041173396 @default.
- W2267352598 cites W2041966202 @default.
- W2267352598 cites W2042296815 @default.
- W2267352598 cites W204301385 @default.
- W2267352598 cites W2043174141 @default.
- W2267352598 cites W2043824636 @default.
- W2267352598 cites W2045077916 @default.