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• W2267424531 abstract "Abstract White spot syndrome virus ( WSSV ), an aquatic virus infecting shrimps and other crustaceans, is widely distributed in Asian subcontinents including India. The infection has led to a serious economic loss in shrimp farming. The WSSV genome is approximately 300 kb and codes for several proteins mediating the infection. The envelope proteins VP 26 and VP 28 play a major role in infection process and also in the interaction with the host cells. A comprehensive study on the viral proteins leading to the development of safe and potent antiviral therapeutic is of adverse need. The novel synthesized compound 3‐(1‐chloropiperidin‐4‐yl)‐6‐fluoro benzisoxazole 2 is proved to have potent antiviral activity against WSSV . The compound antiviral activity is validated in freshwater crabs ( Paratelphusa hydrodomous) . An in silico molecular docking and simulation analysis of the envelope proteins VP 26 and VP 28 with the ligand 3‐(1‐chloropiperidin‐4‐yl)‐6‐fluoro benzisoxazole 2 are carried out. The docking analysis reveals that the polar amino acids in the pore region of the envelope proteins were involved in the ligand binding. The influence of the ligand binding on the proteins is validated by the molecular dynamics and simulation study. These in silico approaches together demonstrate the ligand's efficiency in preventing the trimers from exhibiting their physiological function." @default.
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• W2267424531 date "2016-02-05" @default.
• W2267424531 modified "2023-10-17" @default.
• W2267424531 title "Molecular docking and simulation studies of 3-(1-chloropiperidin-4-yl)-6-fluoro benzisoxazole 2 against VP26 and VP28 proteins of white spot syndrome virus" @default.
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• W2267424531 doi "https://doi.org/10.1111/jfd.12454" @default.
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