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- W2267490693 abstract "In order to investigate the mechanism of gastric mucosal changes which may occur in cirrhosis of the liver for 6 weeks, the author studied the histologic and ultrastructural features of gastric mucosal microvas-culature in Sprague Dawley rats with cirrhosis produced by complete bile duct ligation, as well as portal hypertension produced by partial vein ligation in control rats for 24 hours and 48 hours. The results were summarized as follows: 1) Morphometric analysis disclosed a more significantly increased mucosal capillary cross-sectional area in the cirrhosis group and portal hypertensive group than in the controls (p<0.01) 2)Morphometic analysis of transmission electron micrographs demonstrated that in the cirrhosis and portal hypertensive group the gastric mucosal capillary endothelium had a signigicantly increased cytoplasmic area (p<0.001), decreased capillary lumen (p<0.001) as well as decreased pinocytic vesicle number (p<0.05) compared to the respective parameters in the normal contrl rats. All these findings suggest that in cirrhosis of the liver portal hypertension produces microvascular changes in the gastric mucosa resultion in gastric hypoperfusion. This may play a certain role for the gastric mucosal lesion that can be observed in cirrhosis of the liver." @default.
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- W2267490693 date "1991-01-01" @default.
- W2267490693 modified "2023-09-27" @default.
- W2267490693 title "Morphometric study on gastric microvasculature in liver cirrhosis and portal hypertensive rats." @default.
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