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• W2267526330 abstract "Rtr1p is a phosphatase that impacts gene expression by modulating the phosphorylation status of the C-terminal domain of the large subunit of RNA polymerase II. Here, we show that Rtr1p is a component of a novel mRNA degradation pathway that promotes its autoregulation through turnover of its own mRNA. We show that the 3′UTR of the RTR1 mRNA contains a cis element that destabilizes this mRNA. RTR1 mRNA turnover is achieved through binding of Rtr1p to the RTR1 mRNP in a manner that is dependent on this cis element. Genetic evidence shows that Rtr1p-mediated decay of the RTR1 mRNA involves the 5′-3′ DExD/H-box RNA helicase Dhh1p and the 3′-5′ exonucleases Rex2p and Rex3p. Rtr1p and Rex3p are found associated with Dhh1p, suggesting a model for recruiting the REX exonucleases to the RTR1 mRNA for degradation. Rtr1p-mediated decay potentially impacts additional transcripts, including the unspliced BMH2 pre-mRNA. We propose that Rtr1p may imprint its RNA targets cotranscriptionally and determine their downstream degradation mechanism by directing these transcripts to a novel turnover pathway that involves Rtr1p, Dhh1p, and the REX family of exonucleases." @default.
• W2267526330 created "2016-06-24" @default.
• W2267526330 creator A5021584326 @default.
• W2267526330 creator A5030034318 @default.
• W2267526330 creator A5049057337 @default.
• W2267526330 date "2016-02-03" @default.
• W2267526330 modified "2023-09-27" @default.
• W2267526330 title "The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases" @default.
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• W2267526330 doi "https://doi.org/10.1261/rna.055723.115" @default.
• W2267526330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4793211" @default.
• W2267526330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26843527" @default.
• W2267526330 hasPublicationYear "2016" @default.
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