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- W2267623911 abstract "A study was made of the capacity of vesicular stomatitis virus (VSV) and representative paramyxoviruses to multiply in Epstein-Barr (EB) “virus-rich” (P3J-EB+) and “virus-poor” (P3J-EB−) sublines of the P3J (Jijoye) strain of Burkitt lymphoma cells. Burkitt cells did not require pretreatment with phytohemagglutinin to support virus replication. VSV reached a titer of about 105.5 plaque-forming units/ml in both cell lines. About 95% of cells were destroyed. Mumps virus also multiplied in both cell lines (about 104.7 TCID50/ml) but was cytopathic (cells stained with trypan blue) to only about 50% of the cells. Parainfluenza viruses differed in their infectivity for the test cell lines. Parainfluenza virus, type 1, increased 16- to 32-fold, but was cytopathic to only about 20% of the cells. Parainfluenza virus, type 2, reached a titer of about 105.5 TCID50/ml in both cell lines. It also was cytopathic to only about 20% of the cells. In contrast, parainfluenza virus, type 3, attained a titer of 107.6 TCID50/ml in both cell lines and destroyed about 85% of the cells. Measles virus reached a titer of about 104 TCID50/ml in both cell lines and was cytopathic to about 80% of cells. Measles virus fused cells; large polykaryons formed within 9–48 hours after infection. There was no evidence for an increase in EB virus particles in cells fused by measles virus or superinfected with the other test viruses." @default.
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- W2267623911 date "1970-06-01" @default.
- W2267623911 modified "2023-09-27" @default.
- W2267623911 title "Multiplication of Viruses in Burkitt Lymphoma Cells<xref ref-type=fn rid=FN2>2</xref>" @default.
- W2267623911 doi "https://doi.org/10.1093/jnci/44.6.1231" @default.
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