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- W2267678971 endingPage "C1159" @default.
- W2267678971 startingPage "C1149" @default.
- W2267678971 abstract "The migration of intestinal cells is important in the development and maintenance of normal epithelium, in a process that may be regulated by growth factors and cytokines. Although a number of growth factor receptors are expressed by intestinal cells, little progress has been made toward assignment of functional roles for these ligand-receptor systems. This study compares several growth factors and cytokines for their chemoattraction of the mouse small intestinal epithelial cell line. Epidermal and hepatocyte growth factors stimulated a rapid 30-fold chemotaxis of cells with delayed threefold migration toward transforming growth factor-beta1. Despite stimulating proliferation, keratinocyte, fibroblast, or insulin-like growth factors did not stimulate directed migration. Chemotaxis required tyrosine kinase and phosphatidylinositol phospholipase C activities but not protein kinase C or mitogen-activated protein kinase activity. These findings suggest that the repertoire of growth factors capable of regulating directed intestinal epithelial cell migration is limited and that a divergence exists in the signal transduction pathways for directed vs. nondirected migration." @default.
- W2267678971 created "2016-06-24" @default.
- W2267678971 creator A5003460722 @default.
- W2267678971 creator A5014815275 @default.
- W2267678971 date "1999-12-01" @default.
- W2267678971 modified "2023-10-17" @default.
- W2267678971 title "Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line" @default.
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- W2267678971 doi "https://doi.org/10.1152/ajpcell.1999.277.6.c1149" @default.
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