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- W2267685090 abstract "MicroRNAs (miRNAs) are small non-coding RNA molecules that modulate expression of the majority of genes by inhibiting protein translation. Growing literature has identified functional roles for miRNAs across a broad range of biological processes. As such, miRNAs are recognised as potential disease biomarkers and novel targets for therapies. While several miRNA-targeted therapies are currently in clinical trials (e.g. for the treatment of hepatitis C virus infection and cancer), no therapies have targeted miRNAs in respiratory diseases in the clinic. In this mini-review, we review the current knowledge on miRNA expression and function in respiratory diseases, intervention strategies to target miRNA function and considerations specific to respiratory diseases. Altered miRNA expression profiles have been reported in a number of respiratory diseases, including asthma, chronic obstructive pulmonary disease, cystic fibrosis and idiopathic pulmonary fibrosis. These include alterations in isolated lung tissue, as well as sputum, bronchoalveolar lavage fluids and peripheral blood or serum. The observed alterations in easily accessible body fluids (e.g. serum) have been proposed as new biomarkers that may inform disease diagnosis and patient management. In a subset of studies, miRNA-targeted interventions also improved disease outcomes, indicating functional roles for altered miRNA expression in disease pathogenesis. In fact, direct administration of miRNA-targeting molecules to the lung has yielded promising results in a number of animal models. The ability to directly administer compounds to the lung holds considerable promise and may limit potential off-target effects and side effects caused by the systemic administration required to treat other diseases." @default.
- W2267685090 created "2016-06-24" @default.
- W2267685090 creator A5040579435 @default.
- W2267685090 creator A5043300180 @default.
- W2267685090 creator A5059497342 @default.
- W2267685090 creator A5067305437 @default.
- W2267685090 creator A5090297779 @default.
- W2267685090 date "2016-02-04" @default.
- W2267685090 modified "2023-10-13" @default.
- W2267685090 title "Targeting MicroRNA Function in Respiratory Diseases: Mini-Review" @default.
- W2267685090 cites W144423133 @default.
- W2267685090 cites W1499088821 @default.
- W2267685090 cites W1526700155 @default.
- W2267685090 cites W1742392922 @default.
- W2267685090 cites W1847766730 @default.
- W2267685090 cites W1912771827 @default.
- W2267685090 cites W1966868778 @default.
- W2267685090 cites W1972550382 @default.
- W2267685090 cites W1972989638 @default.
- W2267685090 cites W1974254202 @default.
- W2267685090 cites W1974389984 @default.
- W2267685090 cites W1976639879 @default.
- W2267685090 cites W1978337436 @default.
- W2267685090 cites W1978611909 @default.
- W2267685090 cites W1982554956 @default.
- W2267685090 cites W1986513064 @default.
- W2267685090 cites W1989626257 @default.
- W2267685090 cites W1998865641 @default.
- W2267685090 cites W1999081813 @default.
- W2267685090 cites W2002684710 @default.
- W2267685090 cites W2003388948 @default.
- W2267685090 cites W2006247279 @default.
- W2267685090 cites W2007031153 @default.
- W2267685090 cites W2009001235 @default.
- W2267685090 cites W2010265726 @default.
- W2267685090 cites W2011376139 @default.
- W2267685090 cites W2013029756 @default.
- W2267685090 cites W2013752850 @default.
- W2267685090 cites W2013868665 @default.
- W2267685090 cites W2017120774 @default.
- W2267685090 cites W2017549908 @default.
- W2267685090 cites W2019496443 @default.
- W2267685090 cites W2019858243 @default.
- W2267685090 cites W2022005070 @default.
- W2267685090 cites W2022625680 @default.
- W2267685090 cites W2026099724 @default.
- W2267685090 cites W2026570544 @default.
- W2267685090 cites W2030423721 @default.
- W2267685090 cites W2031613673 @default.
- W2267685090 cites W2031842372 @default.
- W2267685090 cites W2033966391 @default.
- W2267685090 cites W2035908500 @default.
- W2267685090 cites W2037572861 @default.
- W2267685090 cites W2037873524 @default.
- W2267685090 cites W2041349546 @default.
- W2267685090 cites W2042266448 @default.
- W2267685090 cites W2042679507 @default.
- W2267685090 cites W2046314136 @default.
- W2267685090 cites W2047404721 @default.
- W2267685090 cites W2050620145 @default.
- W2267685090 cites W2054109341 @default.
- W2267685090 cites W2054493435 @default.
- W2267685090 cites W2055515566 @default.
- W2267685090 cites W2055614161 @default.
- W2267685090 cites W2057419005 @default.
- W2267685090 cites W2057717266 @default.
- W2267685090 cites W2061113358 @default.
- W2267685090 cites W2065176007 @default.
- W2267685090 cites W2067393348 @default.
- W2267685090 cites W2069009920 @default.
- W2267685090 cites W2069093787 @default.
- W2267685090 cites W2076625645 @default.
- W2267685090 cites W2078656421 @default.
- W2267685090 cites W2079579156 @default.
- W2267685090 cites W2083381199 @default.
- W2267685090 cites W2087032228 @default.
- W2267685090 cites W2087927665 @default.
- W2267685090 cites W2089001345 @default.
- W2267685090 cites W2089595052 @default.
- W2267685090 cites W2090541572 @default.
- W2267685090 cites W2094097897 @default.
- W2267685090 cites W2094369639 @default.
- W2267685090 cites W2095312112 @default.
- W2267685090 cites W2100412847 @default.
- W2267685090 cites W2101411920 @default.
- W2267685090 cites W2101453403 @default.
- W2267685090 cites W2104953797 @default.
- W2267685090 cites W2105549148 @default.
- W2267685090 cites W2111031301 @default.
- W2267685090 cites W2111204049 @default.
- W2267685090 cites W2111316413 @default.
- W2267685090 cites W2112486153 @default.
- W2267685090 cites W2113093407 @default.
- W2267685090 cites W2113645952 @default.
- W2267685090 cites W2115093090 @default.
- W2267685090 cites W2115669722 @default.
- W2267685090 cites W2116799486 @default.
- W2267685090 cites W2117207028 @default.
- W2267685090 cites W2118842534 @default.
- W2267685090 cites W2120055234 @default.