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• W2267732532 abstract "Antimicrobial resistance has decreased PPI-based triple therapy for eradication of H. pylori. The failure rate is almost one quarter of patients with H. pylori infection. The objective of this study was to assess the eradication rate and acceptance of sequential therapy for patients with non-ulcer dyspepsia (NUD). From February 2005 to May 2009, we enrolled 174 patients (Female: 62%; Age: 50.3±10.5 yr) with investigated (EGD or UGI series) NUD. Each patient adopted a 10-day sequential regimen consisting of 40 mg of pantoprazole, 1 g of amoxicillin twice daily for the first 5 days followed by 40 mg of pantoprazole, 500 mg of clarithromycin, and 500 mg of tinidazole twice daily for the remaining 5 days. Eradication was confirmed at least two months after completion of treatment by means of UBT, rapid urease test or histology. Eradication rates were calculated per-protocol and by intention-to-treat. We also used multiple regression models to assess the relationship between age, gender and success rate of eradication. Eradication was achieved in 138 out of 152 who returned for a follow-up test. Thus, the per-protocol cure rate was 90.8%, while intention-to-treat eradication rate was relatively low at 80.2%. Sequential therapy has proven effective in treating ulcer-related H. pylori infection in Southern Europe. In this study, sequential therapy proved effective and well-tolerated for ethnic Chinese NUD patients as well." @default.
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• W2267732532 date "2010-04-01" @default.
• W2267732532 modified "2023-09-24" @default.
• W2267732532 title "The Effectiveness of Sequential Therapy for Non-Ulcer Dyspepsia Patients with H. Pylori Infection" @default.
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• W2267732532 doi "https://doi.org/10.6314/jimt.2010.21(2).05" @default.
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