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- W2267861972 abstract "Prostatectomy represents a standard curative treatment option among men with localized prostate cancer. The chance of requiring additional cancer-directed treatment after prostatectomy in the modern era remains less clear. The purpose of this study was to determine the rate of subsequent cancer-directed treatment in elderly patients with localized prostate cancer who received a radical prostatectomy. Using the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database, we identified men who were diagnosed with localized prostate cancer and treated with radical prostatectomy between years 2004 and 2009. We used Medicare claims data to identify those who received subsequent cancer-directed therapy including non-palliative radiation therapy (defined as ≥25 fractions in a single course of radiation) or androgen deprivation therapy (ADT). The rates of subsequent cancer-directed therapy in the study population were calculated using cumulative incidence analyses with stratification by Gleason score, prostate-specific antigen (PSA), and American Joint Committee on Cancer (AJCC) T stage. We identified 14,157 men with localized prostate cancer who received a radical prostatectomy. The 5-year cumulative incidence of subsequent radiation, subsequent ADT, or any subsequent cancer-directed treatment was 13.0%, 10.5%, and 18.4%, respectively. With stratification by Gleason score (≤6, 7, 8-10), the 5-year rates of any cancer-directed treatment were 7.3%, 18.5%, and 50.7%, respectively (P<.0001). The 5-year rates of any cancer-directed treatment with stratification by PSA (<10, 10≤PSA<20, ≥20) were 16.6%, 27.8%, and 38.5%, respectively (P<.0001). Stratification by AJCC T stage (T2, T3, T4) yielded 5-year rates of any cancer-directed treatment of 11.5%, 43.4%, and 60.2%, respectively (P<.0001). All associations were statistically significant on multivariable analysis (P<.0001). In this population of elderly men with localized prostate cancer, those with higher Gleason scores, PSA, and T stage are at higher risk of receiving subsequent cancer-directed treatment after radical prostatectomy. These findings will help when discussing treatment options and prognosis with patients." @default.
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- W2267861972 date "2015-11-01" @default.
- W2267861972 modified "2023-09-25" @default.
- W2267861972 title "Subsequent Cancer-Directed Therapy After Radical Prostatectomy: A Population-Based Analysis" @default.
- W2267861972 doi "https://doi.org/10.1016/j.ijrobp.2015.07.1150" @default.
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