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- W2267872893 abstract "Right ventricular contractile force and the maximum rate of left ventricular pressure rise were monitored throughout ouabain perfusion of isolated in situ dog hearts. After a 10 to 15% ( partial ouabain ) or an approximate 45% ( full ouabain ) positive inotropic effect had been produced, the hearts were washed by an additional three-minute perfusion with chilled saline. Na + , K + -adenosine triphosphatase (Na + , K + -ATPase), cardiac relaxing system (CRS) and mitochondria were isolated in relatively purified form from these hearts and from control hearts. The Na + , K + -ATPase isolated from the partial and full ouabain perfused hearts was inhibited 31 and 59%, respectively. Calcium binding and uptake by CRS and calcium accumulation and oxidative phosphorylation by mitochondria were unaltered compared to control values. Furthermore, in vitro addition of ouabain (10 -7 to 10 -8 M) was without effect on CRS or mitochondria from both control and ouabain-perfused hearts. It is concluded that the positive inotropic effect of ouabain occurred concomitantly with an effect on Na + , K + -ATPase and that no other persistent biochemical alteration was measurable in the subcellular systems investigated." @default.
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- W2267872893 date "1970-01-01" @default.
- W2267872893 modified "2023-09-28" @default.
- W2267872893 title "Correlation between the inotropic action of ouabain and its effects on subcellular enzyme systems from canine myocardium." @default.
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