Matches in SemOpenAlex for { <https://semopenalex.org/work/W2267895686> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2267895686 endingPage "2299" @default.
- W2267895686 startingPage "2295" @default.
- W2267895686 abstract "The microscopic observation drug susceptibility (MODS) assay has been used for Mycobacterium tuberculosis detection and anti-TB drug susceptibility tests for several years, and our study aimed to evaluate the accuracy of MODS in detecting pyrazinamide resistance in MDR TB suspects.One hundred and forty-eight clinical isolates were collected from 148 MDR TB suspects in the Nanjing Chest Hospital, and the MODS and the mycobacteria growth indicator tube (MGIT) 960 methods for pyrazinamide susceptibility testing were conducted for each isolate independently. pncA gene sequencing was applied to confirm results showing discrepancy between the MODS and MGIT 960 methods. The McNemar χ(2) test was employed to evaluate the paired 2 × 2 table.Compared with the MGIT 960 method, the sensitivity and specificity of the MODS assay were 95.5% and 93.3%, respectively, with a high accuracy of 94.5%. The κ value of 0.89 showed near-perfect agreement for the two methods in determining pyrazinamide susceptibility. Eight clinical isolates showed inconsistent results by MODS and MGIT 960. After sequencing the pncA gene of the eight isolates, MODS and MGIT 960 showed no significant difference in detecting pyrazinamide resistance when compared with pncA gene sequencing (P = 0.655 for MODS and P = 0.564 for MGIT 960).The high accuracy of MODS in detecting pyrazinamide resistance showed that the MODS method would be an alternative for pyrazinamide susceptibility testing; other mutations affecting resistance to pyrazinamide need to be identified in order to elucidate the discrepant results between phenotype- and genotype-based methods." @default.
- W2267895686 created "2016-06-24" @default.
- W2267895686 creator A5025098652 @default.
- W2267895686 creator A5028938025 @default.
- W2267895686 creator A5029940259 @default.
- W2267895686 creator A5047620654 @default.
- W2267895686 creator A5047982627 @default.
- W2267895686 creator A5052830364 @default.
- W2267895686 creator A5064548129 @default.
- W2267895686 creator A5067453012 @default.
- W2267895686 creator A5082920694 @default.
- W2267895686 date "2015-05-07" @default.
- W2267895686 modified "2023-09-25" @default.
- W2267895686 title "The indirect microscopic observation drug susceptibility assay demonstrated high concordance with the indirect MGIT method for pyrazinamide susceptibility testing" @default.
- W2267895686 cites W1805880101 @default.
- W2267895686 cites W1942613564 @default.
- W2267895686 cites W1965013971 @default.
- W2267895686 cites W1976685136 @default.
- W2267895686 cites W1999616279 @default.
- W2267895686 cites W2041910120 @default.
- W2267895686 cites W2046231351 @default.
- W2267895686 cites W2049273999 @default.
- W2267895686 cites W2075505441 @default.
- W2267895686 cites W2077892389 @default.
- W2267895686 cites W2099837270 @default.
- W2267895686 cites W2102030486 @default.
- W2267895686 cites W2115822252 @default.
- W2267895686 cites W2123783730 @default.
- W2267895686 cites W2140934532 @default.
- W2267895686 cites W2146817473 @default.
- W2267895686 cites W2155742575 @default.
- W2267895686 cites W2161340676 @default.
- W2267895686 cites W2164007000 @default.
- W2267895686 doi "https://doi.org/10.1093/jac/dkv112" @default.
- W2267895686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25953803" @default.
- W2267895686 hasPublicationYear "2015" @default.
- W2267895686 type Work @default.
- W2267895686 sameAs 2267895686 @default.
- W2267895686 citedByCount "4" @default.
- W2267895686 countsByYear W22678956862019 @default.
- W2267895686 countsByYear W22678956862020 @default.
- W2267895686 countsByYear W22678956862023 @default.
- W2267895686 crossrefType "journal-article" @default.
- W2267895686 hasAuthorship W2267895686A5025098652 @default.
- W2267895686 hasAuthorship W2267895686A5028938025 @default.
- W2267895686 hasAuthorship W2267895686A5029940259 @default.
- W2267895686 hasAuthorship W2267895686A5047620654 @default.
- W2267895686 hasAuthorship W2267895686A5047982627 @default.
- W2267895686 hasAuthorship W2267895686A5052830364 @default.
- W2267895686 hasAuthorship W2267895686A5064548129 @default.
- W2267895686 hasAuthorship W2267895686A5067453012 @default.
- W2267895686 hasAuthorship W2267895686A5082920694 @default.
- W2267895686 hasBestOaLocation W22678956861 @default.
- W2267895686 hasConcept C114851261 @default.
- W2267895686 hasConcept C126322002 @default.
- W2267895686 hasConcept C142724271 @default.
- W2267895686 hasConcept C2777975735 @default.
- W2267895686 hasConcept C2780459521 @default.
- W2267895686 hasConcept C2781069245 @default.
- W2267895686 hasConcept C71924100 @default.
- W2267895686 hasConcept C86803240 @default.
- W2267895686 hasConcept C89423630 @default.
- W2267895686 hasConceptScore W2267895686C114851261 @default.
- W2267895686 hasConceptScore W2267895686C126322002 @default.
- W2267895686 hasConceptScore W2267895686C142724271 @default.
- W2267895686 hasConceptScore W2267895686C2777975735 @default.
- W2267895686 hasConceptScore W2267895686C2780459521 @default.
- W2267895686 hasConceptScore W2267895686C2781069245 @default.
- W2267895686 hasConceptScore W2267895686C71924100 @default.
- W2267895686 hasConceptScore W2267895686C86803240 @default.
- W2267895686 hasConceptScore W2267895686C89423630 @default.
- W2267895686 hasFunder F4320321001 @default.
- W2267895686 hasIssue "8" @default.
- W2267895686 hasLocation W22678956861 @default.
- W2267895686 hasLocation W22678956862 @default.
- W2267895686 hasOpenAccess W2267895686 @default.
- W2267895686 hasPrimaryLocation W22678956861 @default.
- W2267895686 hasRelatedWork W1989194067 @default.
- W2267895686 hasRelatedWork W2060740592 @default.
- W2267895686 hasRelatedWork W2113890414 @default.
- W2267895686 hasRelatedWork W2120152246 @default.
- W2267895686 hasRelatedWork W2136433194 @default.
- W2267895686 hasRelatedWork W2235084421 @default.
- W2267895686 hasRelatedWork W2369462249 @default.
- W2267895686 hasRelatedWork W2463645194 @default.
- W2267895686 hasRelatedWork W3165151283 @default.
- W2267895686 hasRelatedWork W1494220503 @default.
- W2267895686 hasVolume "70" @default.
- W2267895686 isParatext "false" @default.
- W2267895686 isRetracted "false" @default.
- W2267895686 magId "2267895686" @default.
- W2267895686 workType "article" @default.