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- W2267918549 abstract "We have studied the effect of external x irradiation on the whole-body retention and tissue distribution of gallium-67 ($sup 67$Ga) in mice over a period of 20 days. Adult male C57BL/6 Cum mice were injected intraperitoneally with 5 $mu$Ci $sup 67$Ga 24 hr before, immediately before, immediately after, or 24 hr after whole-body x-ray exposure to 450 R. Control mice received $sup 67$Ga injections and sham irradiation. Increased excretion and reduced soft-tissue concentrations of $sup 67$Ga occurred in irradiated mice. The greatest effect was observed when the radionuclide was injected 24 hr after irradiation and assayed 24 hr later. An analysis of variance of the retention data showed that the differences between the groups were significant at the 99 percent confidence level. Exponential least-squares analysis of whole-body counting results revealed three compartments in the biological retention data. The long-lived compartment possibly corresponds to $sup 67$Ga bound relatively tightly in certain body tissues and lost slowly. The two remaining compartments have been tentatively identified as circulating unbound $sup 67$Ga that is lost rapidly and circulating bound $sup 67$Ga that is lost less rapidly. (auth)" @default.
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- W2267918549 date "1976-01-01" @default.
- W2267918549 modified "2023-09-27" @default.
- W2267918549 title "Radiation effect on $sup 67$Ga retention and distribution in mouse tissues" @default.
- W2267918549 hasPublicationYear "1976" @default.
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