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- W2267982040 endingPage "e1005776" @default.
- W2267982040 startingPage "e1005776" @default.
- W2267982040 abstract "Thymic medullary regions are formed in neonatal mice as islet-like structures, which increase in size over time and eventually fuse a few weeks after birth into a continuous structure. The development of medullary thymic epithelial cells (TEC) is dependent on NF-κB associated signaling though other signaling pathways may contribute. Here, we demonstrate that Stat3-mediated signals determine medullary TEC cellularity, architectural organization and hence the size of the medulla. Deleting Stat3 expression selectively in thymic epithelia precludes the postnatal enlargement of the medulla retaining a neonatal architecture of small separate medullary islets. In contrast, loss of Stat3 expression in cortical TEC neither affects the cellularity or organization of the epithelia. Activation of Stat3 is mainly positioned downstream of EGF-R as its ablation in TEC phenocopies the loss of Stat3 expression in these cells. These results indicate that Stat3 meditated signal via EGF-R is required for the postnatal development of thymic medullary regions." @default.
- W2267982040 created "2016-06-24" @default.
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- W2267982040 date "2016-01-20" @default.
- W2267982040 modified "2023-09-25" @default.
- W2267982040 title "Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells" @default.
- W2267982040 cites W1507810077 @default.
- W2267982040 cites W1511000426 @default.
- W2267982040 cites W1583729352 @default.
- W2267982040 cites W1696746030 @default.
- W2267982040 cites W1776790137 @default.
- W2267982040 cites W1925268733 @default.
- W2267982040 cites W1939607990 @default.
- W2267982040 cites W1964974221 @default.
- W2267982040 cites W1973261871 @default.
- W2267982040 cites W1973454407 @default.
- W2267982040 cites W1980133038 @default.
- W2267982040 cites W1980896849 @default.
- W2267982040 cites W1981663030 @default.
- W2267982040 cites W1983113497 @default.
- W2267982040 cites W1986053199 @default.
- W2267982040 cites W1992856202 @default.
- W2267982040 cites W1993107235 @default.
- W2267982040 cites W1993153481 @default.
- W2267982040 cites W1993183180 @default.
- W2267982040 cites W1993405888 @default.
- W2267982040 cites W1993879046 @default.
- W2267982040 cites W1995790934 @default.
- W2267982040 cites W2008356343 @default.
- W2267982040 cites W2008582777 @default.
- W2267982040 cites W2011780533 @default.
- W2267982040 cites W2017082201 @default.
- W2267982040 cites W2018718597 @default.
- W2267982040 cites W2020713861 @default.
- W2267982040 cites W2024700038 @default.
- W2267982040 cites W2024748688 @default.
- W2267982040 cites W2025605686 @default.
- W2267982040 cites W2026875813 @default.
- W2267982040 cites W2028214770 @default.
- W2267982040 cites W2029275361 @default.
- W2267982040 cites W2029665585 @default.
- W2267982040 cites W2032406291 @default.
- W2267982040 cites W2037367542 @default.
- W2267982040 cites W2037931509 @default.
- W2267982040 cites W2039000125 @default.
- W2267982040 cites W2042070921 @default.
- W2267982040 cites W2043911925 @default.
- W2267982040 cites W2045683334 @default.
- W2267982040 cites W2050972863 @default.
- W2267982040 cites W2052397955 @default.
- W2267982040 cites W2056111737 @default.
- W2267982040 cites W2058904843 @default.
- W2267982040 cites W2059734518 @default.
- W2267982040 cites W2061863220 @default.
- W2267982040 cites W2062036642 @default.
- W2267982040 cites W2069109607 @default.
- W2267982040 cites W2071229945 @default.
- W2267982040 cites W2073723168 @default.
- W2267982040 cites W2078730804 @default.
- W2267982040 cites W2082557203 @default.
- W2267982040 cites W2083345299 @default.
- W2267982040 cites W2086004586 @default.
- W2267982040 cites W2100276321 @default.
- W2267982040 cites W2100890363 @default.
- W2267982040 cites W2116700965 @default.
- W2267982040 cites W2120958268 @default.
- W2267982040 cites W2123874786 @default.
- W2267982040 cites W2126308474 @default.
- W2267982040 cites W2130281104 @default.
- W2267982040 cites W2132003377 @default.
- W2267982040 cites W2132433492 @default.
- W2267982040 cites W2134705919 @default.
- W2267982040 cites W2136991900 @default.
- W2267982040 cites W2139771438 @default.
- W2267982040 cites W2141654290 @default.
- W2267982040 cites W2141715328 @default.
- W2267982040 cites W2150328261 @default.
- W2267982040 cites W2153050742 @default.
- W2267982040 cites W2165603811 @default.
- W2267982040 cites W2170860163 @default.
- W2267982040 cites W2172023545 @default.
- W2267982040 cites W4236836803 @default.
- W2267982040 doi "https://doi.org/10.1371/journal.pgen.1005776" @default.
- W2267982040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4720355" @default.
- W2267982040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26789017" @default.
- W2267982040 hasPublicationYear "2016" @default.
- W2267982040 type Work @default.