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• W2267997941 startingPage "4839" @default.
• W2267997941 abstract "Anabaenopeptins isolated from cyanobacteria were identified as inhibitors of carboxypeptidase TAFIa. Cocrystal structures of these macrocyclic natural product inhibitors in a modified porcine carboxypeptidase B revealed their binding mode and provided the basis for the rational design of small molecule inhibitors with a previously unknown central urea motif. Optimization based on these design concepts allowed for a rapid evaluation of the SAR and delivered potent small molecule inhibitors of TAFIa with a promising overall profile." @default.
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• W2267997941 date "2015-05-20" @default.
• W2267997941 modified "2023-09-30" @default.
• W2267997941 title "Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin" @default.
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• W2267997941 doi "https://doi.org/10.1021/jm501840b" @default.
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