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- W2268049150 abstract "The roots and aerial parts of Eschscholzia californica Cham. (Papaveraceae) were extracted with ethanol. Repeated column chromatography, preparative TLC, and crystallization led to the isolation of fourteen isoquinoline alkaloids, the structures of which were determined on the basis of spectroscopic techniques and by comparison with literature values. One of the compounds isolated, 1-(3-hydroxy-4-methoxybenzyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (14), has not previously been isolated from a natural source. All isolated compounds were tested for human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibition activity. None of the compounds isolated significantly inhibited both HuAChE and HuBuChE, but the two benzylisoquinoline alkaloids, reticuline 9 and 14, showed promising inhibitory activity against HuBuChE." @default.
- W2268049150 created "2016-06-24" @default.
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- W2268049150 date "2010-07-01" @default.
- W2268049150 modified "2023-10-13" @default.
- W2268049150 title "Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from <i>Eschscholzia californica</i> (Papaveraceae)" @default.
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- W2268049150 doi "https://doi.org/10.1177/1934578x1000500710" @default.
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