Matches in SemOpenAlex for { <https://semopenalex.org/work/W2268142279> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2268142279 abstract "Intro: Substantial efforts over the past decade have been made to increase rates of IV tPA use in the US. We sought to determine changes in patient characteristics and rates of tPA use over time among hospitalized stroke patients. Methods: We analyzed all acute ischemic stroke (AIS) patients (n=1,093,895) and those arriving ≤ −2 hr and treated with IV tPA ≤ 3 hr of onset (n=50,798) from 2003-2011 in the GWTG-Stroke registry. Categorical data were analyzed by Pearson Chi-square and continuous data by Wilcoxon test, with multivariable GEE models (with and without NIHSS) for analysis of calendar time effect. Results: IV tPA use increased from 4.0% to 7.0% in all AIS admissions, and 42.6% to 77.0% in AIS patients arriving ≤ 2hr and tPA treated ≤ 3 hr (p <0.001) (Figure). In univariate analysis, IV tPA use increased over time in those aged >85 yr, non-white, and with milder strokes (NIHSS 0-4) (Table). Door-to-image time (median 24 vs. 20 min) and door-to -tPA time (median 81 vs. 72 min) also improved, with ~65% of tPA treated patients getting CT <25 min of arrival (Table). Multivariable GEE analysis of the effect of calendar year on rates of tPA use (n= 45656) found an adjusted OR of 1.37 (95%CI 1.35 - 1.40; p < 0.0001) per year. Including NIHSS in the model (n=39814) did not change the results substantially (OR=1.32, CI 1.29 - 1.35; p<0.0001) per yr. Conclusion: The frequency of IV tPA use among all AIS patients, regardless of contraindications, and among eligible patients without contraindications arriving within two hours nearly doubled from 2003-2011. Treatment with tPA has expanded over the past decade to include more stroke patients with milder deficits, non-white race-ethnicity, and in the oldest old." @default.
- W2268142279 created "2016-06-24" @default.
- W2268142279 creator A5008639808 @default.
- W2268142279 creator A5010571732 @default.
- W2268142279 creator A5015783013 @default.
- W2268142279 creator A5016755104 @default.
- W2268142279 creator A5038719267 @default.
- W2268142279 creator A5054440702 @default.
- W2268142279 creator A5070062505 @default.
- W2268142279 creator A5070928171 @default.
- W2268142279 creator A5075359983 @default.
- W2268142279 creator A5088527297 @default.
- W2268142279 date "2013-02-01" @default.
- W2268142279 modified "2023-10-16" @default.
- W2268142279 title "Abstract 103: Temporal Trends in Patient Characteristics and Use of IV tPA in Acute Ischemic Stroke Patients Treated at GWTG-Stroke Hospitals" @default.
- W2268142279 doi "https://doi.org/10.1161/str.44.suppl_1.a103" @default.
- W2268142279 hasPublicationYear "2013" @default.
- W2268142279 type Work @default.
- W2268142279 sameAs 2268142279 @default.
- W2268142279 citedByCount "1" @default.
- W2268142279 countsByYear W22681422792020 @default.
- W2268142279 crossrefType "journal-article" @default.
- W2268142279 hasAuthorship W2268142279A5008639808 @default.
- W2268142279 hasAuthorship W2268142279A5010571732 @default.
- W2268142279 hasAuthorship W2268142279A5015783013 @default.
- W2268142279 hasAuthorship W2268142279A5016755104 @default.
- W2268142279 hasAuthorship W2268142279A5038719267 @default.
- W2268142279 hasAuthorship W2268142279A5054440702 @default.
- W2268142279 hasAuthorship W2268142279A5070062505 @default.
- W2268142279 hasAuthorship W2268142279A5070928171 @default.
- W2268142279 hasAuthorship W2268142279A5075359983 @default.
- W2268142279 hasAuthorship W2268142279A5088527297 @default.
- W2268142279 hasConcept C105795698 @default.
- W2268142279 hasConcept C126322002 @default.
- W2268142279 hasConcept C127413603 @default.
- W2268142279 hasConcept C144301174 @default.
- W2268142279 hasConcept C164705383 @default.
- W2268142279 hasConcept C27403532 @default.
- W2268142279 hasConcept C2776572282 @default.
- W2268142279 hasConcept C2780645631 @default.
- W2268142279 hasConcept C3020166492 @default.
- W2268142279 hasConcept C3020199598 @default.
- W2268142279 hasConcept C33923547 @default.
- W2268142279 hasConcept C38180746 @default.
- W2268142279 hasConcept C53084192 @default.
- W2268142279 hasConcept C541997718 @default.
- W2268142279 hasConcept C71924100 @default.
- W2268142279 hasConcept C78519656 @default.
- W2268142279 hasConceptScore W2268142279C105795698 @default.
- W2268142279 hasConceptScore W2268142279C126322002 @default.
- W2268142279 hasConceptScore W2268142279C127413603 @default.
- W2268142279 hasConceptScore W2268142279C144301174 @default.
- W2268142279 hasConceptScore W2268142279C164705383 @default.
- W2268142279 hasConceptScore W2268142279C27403532 @default.
- W2268142279 hasConceptScore W2268142279C2776572282 @default.
- W2268142279 hasConceptScore W2268142279C2780645631 @default.
- W2268142279 hasConceptScore W2268142279C3020166492 @default.
- W2268142279 hasConceptScore W2268142279C3020199598 @default.
- W2268142279 hasConceptScore W2268142279C33923547 @default.
- W2268142279 hasConceptScore W2268142279C38180746 @default.
- W2268142279 hasConceptScore W2268142279C53084192 @default.
- W2268142279 hasConceptScore W2268142279C541997718 @default.
- W2268142279 hasConceptScore W2268142279C71924100 @default.
- W2268142279 hasConceptScore W2268142279C78519656 @default.
- W2268142279 hasIssue "suppl_1" @default.
- W2268142279 hasLocation W22681422791 @default.
- W2268142279 hasOpenAccess W2268142279 @default.
- W2268142279 hasPrimaryLocation W22681422791 @default.
- W2268142279 hasRelatedWork W1984555837 @default.
- W2268142279 hasRelatedWork W2086451209 @default.
- W2268142279 hasRelatedWork W2363636480 @default.
- W2268142279 hasRelatedWork W2369885165 @default.
- W2268142279 hasRelatedWork W2387448955 @default.
- W2268142279 hasRelatedWork W2624469398 @default.
- W2268142279 hasRelatedWork W2896008739 @default.
- W2268142279 hasRelatedWork W2898016454 @default.
- W2268142279 hasRelatedWork W3122900209 @default.
- W2268142279 hasRelatedWork W4293570004 @default.
- W2268142279 hasVolume "44" @default.
- W2268142279 isParatext "false" @default.
- W2268142279 isRetracted "false" @default.
- W2268142279 magId "2268142279" @default.
- W2268142279 workType "article" @default.