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- W2268171034 abstract "1572 Objectives It has been proposed that the stimulated serum thyroglobulin assay (Tg) after ablation of the thyroid gland, can be the sole screening test for differentiated thyroid cancer recurrence in low risk patients. This is particularly so if the first post therapy whole body I-131 scan (WBS), Tg, and circulating thyroglobulin antibodies (aTg) are all negative(-ve). However, the frequency of a positive (+ve) WBS (defined as iodine avid tissue in the thyroid bed or in potential metastases) and -ve Tg/aTg remains unclear. We aim to detect the frequency of a +ve WBS with negative (-ve) Tg in thyroid cancer pts presenting for nuclear medicine I-131 WBS. Methods 201 consecutive patients over a two year period were identified from the Alfred hospital database as having either post ablation therapy (TWBS) or low dose (2-3 mCi) diagnostic WBS scans (DWBS). Demographic data, tumour type, method of stimulation (rhTSH or withdrawal), T4, TSH, Tg, dose of I-131, detectable remnant size and aTg levels were collected on each patient (196 complete data sets) . Tg Results (CI= 95% confidence limits) 4 / 29 TWBS (all 4 high risk) and 1/6 DWBS patients (high risk) who were scan positive and Tg/aTg negative had possible metastatic disease. No statistically significant difference was observed between groups prepared with withdrawal compared to rhTSH. Conclusions The rate of -ve Tg/ aTg with evidence of a +ve WBS is 25 % in post ablation patients and 7% in diagnostic WBS patients. This compares to scan negative and thyroglobulin positive patients at 4% and 22% respectively. The DWBS data appear to support sole use of Tg in low risk thyroid cancer patient surveillance post ablation" @default.
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- W2268171034 date "2010-05-01" @default.
- W2268171034 modified "2023-09-28" @default.
- W2268171034 title "Frequency of undetectable serum thyroglobulin and thyroglobulin antibody but whole body I-131 positive scans in thyroid cancer patients" @default.
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