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- W2268307692 abstract "目的 研究β-淀粉样蛋白(βAP)对衰老大鼠学习记忆能力及海马Na^+-K^+ATP酶活性的影响。方法 用D-半乳糖(D-gal)建立衰老动物模型,海马内微注射βAP,检测各组大鼠Y-迷宫分辨学习和一次性被动回避反应的变化,并测定海马 Na^+-K^+ATP酶活性。结果 D-gal-βAP组学习记忆能力,与其他各组比较有显著性差异(P<0.05,P<0.01);Na^+-K^+ATP酶组(P<0.05)。与NS+NS组比较有极显著性差异(P<0.01)。结论 βAP与D-gal联合使用可导致脑海马自由基损伤加重 ,学习记忆能力显著减弱,海马Na^+-K^+ATP酶活性显著降低。" @default.
- W2268307692 created "2016-06-24" @default.
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- W2268307692 date "2000-11-20" @default.
- W2268307692 modified "2023-09-24" @default.
- W2268307692 title "β-淀粉样蛋白对衰老模型大鼠学习记忆能力及脑海马Na+-K+ATP酶活性的影响" @default.
- W2268307692 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2000.06.003" @default.
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