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- W2268381236 endingPage "11" @default.
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- W2268381236 abstract "The zebrafish (Danio rerio) has been increasingly explored in pharmaceutical research as a promising alternative model for toxicological screens. This necessitates a thorough knowledge on the biotransformation processes for a correct interpretation of pharmacological and toxicological data. Physiologically, cytochrome P450 (CYP) enzymes, specifically CYP families 1-3, play a pivotal role in drug metabolism. And yet, information regarding activity of CYP, its isoforms, and conjugation enzymes in zebrafish is either scarce or conflicting. To account for this discrepancy, the available spatiotemporal, modulation and activity data on zebrafish CYP 1-3 families are reviewed in this paper and compared with human CYP data. The CYP genetic features and synteny are well characterized, as is their expression in different organ systems. Moreover, several substrates metabolized by humans also show metabolism in zebrafish, with other CYP isoforms possibly involved. Altogether, the five CYP1 members, 41 CYP2 members and five CYP3 members in zebrafish show distinct evolutionary and orthological similarities with humans." @default.
- W2268381236 created "2016-06-24" @default.
- W2268381236 creator A5003821661 @default.
- W2268381236 creator A5007117583 @default.
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- W2268381236 creator A5046103708 @default.
- W2268381236 creator A5063501039 @default.
- W2268381236 creator A5073036123 @default.
- W2268381236 date "2016-01-01" @default.
- W2268381236 modified "2023-10-06" @default.
- W2268381236 title "Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3" @default.
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- W2268381236 doi "https://doi.org/10.2131/jts.41.1" @default.
- W2268381236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26763387" @default.