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• W2268543173 abstract "Here I describe a scenario that explains how life could have originated through molecular coevolution. When the Earth was warm, organic matter partitioned into an oil slick on the ocean’s surface, an aqueous layer with low concentrations of soluble organic substances and a benthic “kerogen” layer. The interface between the oil slick and the aqueous layer is proposed to be where life began. The overlying oil slick could generate complex monomers and polymers through dehydration reactions and photochemistry. The interface between polar and hydrophobic layers would be enriched with amphiphiles that could retain biologically important molecules at the site. Environmental cycles of suitable periodicity could entrain nucleic acid replication. Peptides enriched with arginine play a pivotal role. They aggregate nucleic acids (NA), preventing dispersal and aiding replication and elongation. Furthermore, arginine’s guanidium group forms high-energy phosphate bonds able to catalyze energy transfer during NA replication and peptide synthesis. Thus, families of NAs that helped incorporate arginine into peptides comprise the core of the first living system. A specific candidate is proposed for the protobiont, based on an autocomplementary NA sequence that bears arginine’s codon and anticodon and demonstrates stereospecific affinity for this amino acid. The relationship between arginine and these NA strands represents the first step in the genetic code’s evolution. Subsequent elaboration of the code occurred through molecular coevolution, natural selection favoring the retention, and replication of NA that helped make peptides with properties useful to evolving biological systems. Early in biological evolution, there were no barriers to the free exchange of nucleic acids. Thus genetic combinations that functioned cooperatively would have easily formed, increased through natural selection, and spread throughout a global set of interactive “composomes” near the ocean’s surface." @default.
• W2268543173 created "2016-06-24" @default.
• W2268543173 creator A5031745083 @default.
• W2268543173 date "2012-01-01" @default.
• W2268543173 modified "2023-10-17" @default.
• W2268543173 title "Oceanic Arginine Translator: The Origin of Life and Early Evolution of the Genetic Code" @default.
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• W2268543173 doi "https://doi.org/10.1007/978-94-007-2941-4_33" @default.
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