Matches in SemOpenAlex for { <https://semopenalex.org/work/W2268691230> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2268691230 endingPage "29" @default.
- W2268691230 startingPage "210" @default.
- W2268691230 abstract "1. A number of naphthoquinones were found to inhibit glycolysis of adult Schistosoma mansoni in low concentrations. The relationship between structural characteristics and antiglycolytic activity has been studied.2. The antiglycolytic activity of these compounds against S. mansoni is markedly reduced in the presence of serum.3. The chemotherapeutic activity of naphthoquinones against S. mansoni in mice is of a very low order and cannot be demonstrated when these compounds are administered alone. Some of them, e.g., 2-methyl-1,4-naphthoquinone, enhance slightly the chemotherapeutic effect of organic antimonials. This synergism is considered to be of a magnitude insufficient to warrant clinical trial.4. The results obtained indicate that naphthoquinones inhibit glycolysis of S. mansoni by a mechanism different from those which produce inhibition of respiration of malaria parasites and of snails, of the activity of brain choline acetylase and of the glycolysis of mammalian tissues and of T. equiperdum. Furthermore, inactivation of sulfhydryl groups does not appear to explain the antiglycolytic effect of naphthoquinones against schistosomes." @default.
- W2268691230 created "2016-06-24" @default.
- W2268691230 creator A5007597889 @default.
- W2268691230 creator A5087474923 @default.
- W2268691230 date "1951-02-01" @default.
- W2268691230 modified "2023-09-23" @default.
- W2268691230 title "Effect of naphthoquinones on Schistosoma mansoni in vitro and in vivo." @default.
- W2268691230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14814617" @default.
- W2268691230 hasPublicationYear "1951" @default.
- W2268691230 type Work @default.
- W2268691230 sameAs 2268691230 @default.
- W2268691230 citedByCount "13" @default.
- W2268691230 countsByYear W22686912302013 @default.
- W2268691230 countsByYear W22686912302014 @default.
- W2268691230 crossrefType "journal-article" @default.
- W2268691230 hasAuthorship W2268691230A5007597889 @default.
- W2268691230 hasAuthorship W2268691230A5087474923 @default.
- W2268691230 hasConcept C150903083 @default.
- W2268691230 hasConcept C165901193 @default.
- W2268691230 hasConcept C185592680 @default.
- W2268691230 hasConcept C20251656 @default.
- W2268691230 hasConcept C202751555 @default.
- W2268691230 hasConcept C203014093 @default.
- W2268691230 hasConcept C207001950 @default.
- W2268691230 hasConcept C2776225656 @default.
- W2268691230 hasConcept C2776863245 @default.
- W2268691230 hasConcept C2778491710 @default.
- W2268691230 hasConcept C55493867 @default.
- W2268691230 hasConcept C62231903 @default.
- W2268691230 hasConcept C86803240 @default.
- W2268691230 hasConcept C98274493 @default.
- W2268691230 hasConceptScore W2268691230C150903083 @default.
- W2268691230 hasConceptScore W2268691230C165901193 @default.
- W2268691230 hasConceptScore W2268691230C185592680 @default.
- W2268691230 hasConceptScore W2268691230C20251656 @default.
- W2268691230 hasConceptScore W2268691230C202751555 @default.
- W2268691230 hasConceptScore W2268691230C203014093 @default.
- W2268691230 hasConceptScore W2268691230C207001950 @default.
- W2268691230 hasConceptScore W2268691230C2776225656 @default.
- W2268691230 hasConceptScore W2268691230C2776863245 @default.
- W2268691230 hasConceptScore W2268691230C2778491710 @default.
- W2268691230 hasConceptScore W2268691230C55493867 @default.
- W2268691230 hasConceptScore W2268691230C62231903 @default.
- W2268691230 hasConceptScore W2268691230C86803240 @default.
- W2268691230 hasConceptScore W2268691230C98274493 @default.
- W2268691230 hasIssue "2" @default.
- W2268691230 hasLocation W22686912301 @default.
- W2268691230 hasOpenAccess W2268691230 @default.
- W2268691230 hasPrimaryLocation W22686912301 @default.
- W2268691230 hasRelatedWork W1610479235 @default.
- W2268691230 hasRelatedWork W1821593899 @default.
- W2268691230 hasRelatedWork W2012655535 @default.
- W2268691230 hasRelatedWork W2029167770 @default.
- W2268691230 hasRelatedWork W2106281371 @default.
- W2268691230 hasRelatedWork W2732595704 @default.
- W2268691230 hasRelatedWork W2766081075 @default.
- W2268691230 hasRelatedWork W2895471138 @default.
- W2268691230 hasRelatedWork W3027610313 @default.
- W2268691230 hasRelatedWork W3147606893 @default.
- W2268691230 hasVolume "101" @default.
- W2268691230 isParatext "false" @default.
- W2268691230 isRetracted "false" @default.
- W2268691230 magId "2268691230" @default.
- W2268691230 workType "article" @default.