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- W2268703079 abstract "We have studied the uptake of 3H-dopamine, 3H-norepinephrine and the 3H-tetrahydroisoquinoline alkaloids derived from these 3H-catecholamines by condensation with acetaldehyde. The alkaloids and the catecholamines accumulated in the tissue to several times their concentrations in the medium. Alkaloid uptake was much less than catecholamine uptake when these substances were compared at 10-6 M; differences were less marked at 10-6 M as a result of saturation of the catecholamine uptake mechanism. We have also studied the effect of a nonradioactive, dopamine-derived tetrahydroisoquinoline alkaloid (salsolinol) on the uptake of 3H-catecholamines. Salsolinol inhibited the accumulation of catecholamines. This inhibition was concentration dependent over the range 10-5 to 10-8 M; inhibition was less than that observed with reserpine or desmethylimipramine. When salsolinol was added after 3H-catecholamines had accumulated in the tissue, there was release of 3H-catecholamines into the medium. These observations are consistent with the point of view that tetrahydroisoquinoline alkaloids may play an important role in alcoholism." @default.
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- W2268703079 date "1971-11-01" @default.
- W2268703079 modified "2023-10-16" @default.
- W2268703079 title "Tetrahydroisoquinoline alkaloids: uptake by rat brain homogenates and inhibition of catecholamine uptake." @default.
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