FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2268703273> ?p ?o ?g. }

• W2268703273 endingPage "1148" @default.
• W2268703273 startingPage "1140" @default.
• W2268703273 abstract "The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness. Here we report on the development of the first potent and selective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogues in leukemia cells. Boronate 30 displays a promising in vitro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeability and CYP inhibition, deeming it a suitable compound for in vivo studies." @default.
• W2268703273 created "2016-06-24" @default.
• W2268703273 creator A5001182200 @default.
• W2268703273 creator A5001780639 @default.
• W2268703273 creator A5003918697 @default.
• W2268703273 creator A5005356850 @default.
• W2268703273 creator A5006061477 @default.
• W2268703273 creator A5012532551 @default.
• W2268703273 creator A5012892811 @default.
• W2268703273 creator A5013277256 @default.
• W2268703273 creator A5016862759 @default.
• W2268703273 creator A5026244319 @default.
• W2268703273 creator A5029296072 @default.
• W2268703273 creator A5037529507 @default.
• W2268703273 creator A5038189076 @default.
• W2268703273 creator A5040725620 @default.
• W2268703273 creator A5043757560 @default.
• W2268703273 creator A5044527103 @default.
• W2268703273 creator A5047086301 @default.
• W2268703273 creator A5047470728 @default.
• W2268703273 creator A5052098655 @default.
• W2268703273 creator A5054798676 @default.
• W2268703273 creator A5062560670 @default.
• W2268703273 creator A5073818850 @default.
• W2268703273 creator A5079220895 @default.
• W2268703273 creator A5085546344 @default.
• W2268703273 creator A5086792779 @default.
• W2268703273 creator A5087327635 @default.
• W2268703273 creator A5088390075 @default.
• W2268703273 creator A5090204935 @default.
• W2268703273 creator A5091081254 @default.
• W2268703273 date "2016-01-27" @default.
• W2268703273 modified "2023-10-10" @default.
• W2268703273 title "Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1" @default.
• W2268703273 cites W1864133223 @default.
• W2268703273 cites W1968310807 @default.
• W2268703273 cites W1970838318 @default.
• W2268703273 cites W1971180232 @default.
• W2268703273 cites W1981761179 @default.
• W2268703273 cites W1990463372 @default.
• W2268703273 cites W1993251792 @default.
• W2268703273 cites W1998101586 @default.
• W2268703273 cites W2002397312 @default.
• W2268703273 cites W2004142027 @default.
• W2268703273 cites W2030545256 @default.
• W2268703273 cites W2036194106 @default.
• W2268703273 cites W2039648313 @default.
• W2268703273 cites W2039870976 @default.
• W2268703273 cites W2047985441 @default.
• W2268703273 cites W2061194648 @default.
• W2268703273 cites W2068756510 @default.
• W2268703273 cites W2072591546 @default.
• W2268703273 cites W2079029484 @default.
• W2268703273 cites W2096439168 @default.
• W2268703273 cites W2096885367 @default.
• W2268703273 cites W2140889813 @default.
• W2268703273 cites W2154122246 @default.
• W2268703273 cites W2163495162 @default.
• W2268703273 cites W2169590701 @default.
• W2268703273 cites W2232037665 @default.
• W2268703273 cites W2313595807 @default.
• W2268703273 cites W2328081443 @default.
• W2268703273 cites W2950813734 @default.
• W2268703273 doi "https://doi.org/10.1021/acs.jmedchem.5b01741" @default.
• W2268703273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4753678" @default.
• W2268703273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26771665" @default.
• W2268703273 hasPublicationYear "2016" @default.
• W2268703273 type Work @default.
• W2268703273 sameAs 2268703273 @default.
• W2268703273 citedByCount "36" @default.
• W2268703273 countsByYear W22687032732016 @default.
• W2268703273 countsByYear W22687032732017 @default.
• W2268703273 countsByYear W22687032732018 @default.
• W2268703273 countsByYear W22687032732019 @default.
• W2268703273 countsByYear W22687032732020 @default.
• W2268703273 countsByYear W22687032732021 @default.
• W2268703273 countsByYear W22687032732022 @default.
• W2268703273 countsByYear W22687032732023 @default.
• W2268703273 crossrefType "journal-article" @default.
• W2268703273 hasAuthorship W2268703273A5001182200 @default.
• W2268703273 hasAuthorship W2268703273A5001780639 @default.
• W2268703273 hasAuthorship W2268703273A5003918697 @default.
• W2268703273 hasAuthorship W2268703273A5005356850 @default.
• W2268703273 hasAuthorship W2268703273A5006061477 @default.
• W2268703273 hasAuthorship W2268703273A5012532551 @default.
• W2268703273 hasAuthorship W2268703273A5012892811 @default.
• W2268703273 hasAuthorship W2268703273A5013277256 @default.
• W2268703273 hasAuthorship W2268703273A5016862759 @default.
• W2268703273 hasAuthorship W2268703273A5026244319 @default.
• W2268703273 hasAuthorship W2268703273A5029296072 @default.
• W2268703273 hasAuthorship W2268703273A5037529507 @default.
• W2268703273 hasAuthorship W2268703273A5038189076 @default.
• W2268703273 hasAuthorship W2268703273A5040725620 @default.
• W2268703273 hasAuthorship W2268703273A5043757560 @default.
• W2268703273 hasAuthorship W2268703273A5044527103 @default.
• W2268703273 hasAuthorship W2268703273A5047086301 @default.
• W2268703273 hasAuthorship W2268703273A5047470728 @default.
• W2268703273 hasAuthorship W2268703273A5052098655 @default.

• next