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- W2268712441 abstract "Many regiment have been tried to eradicate Heliccobacter pylori (Hp) in duodenal and gastric ulcers. Lansoprazole, a new proton pump inhibitor, is effective as adjuvant therapy for Hp eradication. In this study, we evaluated the efficacy of a new triple therapy for Hp associated gastric ulcers containing two weeks of treatment with lansoprazole (30 mg bid),clarithromycin (250 mg qid), and amoxicillin (500 mg qid). Thirty patients were enrolled, of whom 24 completed the study. Four weeks after completion of the regiment, follow up endoscopy revealed ulcer healing in 91.6% (22/24) of patients, with complete healing in 70.8%(17/24). The Hp eradication rate was 66.7%(16/24). Delayed healing of the ulcers was significantly associated with the size of ulcer , but not with persistence of Hp. Six of 30 (20%) patients experienced side effects, including diarrhea, alopecia, insomnia, an oral ulcer, nausea, dry mouth, numbness, and bitter sensation. In conclusion, lansoprazole triple therapy is effective for Hp eradication in gastric ulcers. For a higher eradication rate, patient compliance and drug resistance should be further studied.(Tzu Chi Med J 1996;8: 191-196)" @default.
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- W2268712441 date "1996-09-01" @default.
- W2268712441 modified "2023-09-28" @default.
- W2268712441 title "Lansoprazole-containing Triple therapy on Helicobacter Pylori Associated Gastric Ulcers" @default.
- W2268712441 doi "https://doi.org/10.6440/tzucmj.199609.0191" @default.
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