FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2268783256> ?p ?o ?g. }

• W2268783256 endingPage "1440" @default.
• W2268783256 startingPage "1433" @default.
• W2268783256 abstract "Myocardial ischemia-reperfusion (IR) causes widespread cardiomyocyte dysfunction, including apoptosis and necrosis. The present study aimed to investigate the possible cardioprotective effects of p-nitro caffeic acid phenethyl ester (CAPE-NO2) on myocardial IR-induced injury in vivo. To generate a rat model of myocardial IR, the left anterior descending coronary artery was occluded for 30 min, followed by reperfusion for 2 h. The rats were administered either the sham treatment (the sham and IR control groups) or the therapeutic agents [the caffeic acid phenethyl ester (CAPE) and CAPE-NO2 groups] 10 min prior to the occlusion. Myocardial IR-induced injury is characterized by: A significant increase in the levels of myocardial enzymes, including creatine kinase, lactate dehydrogenase and aspartate transaminase; a marked increase in intercellular adhesion molecule 1 expression levels, lipid peroxidation products and inflammatory mediators; and a significant decrease in myocardial antioxidants, including catalase, total superoxide dismutase and glutathione peroxidase. In the present study, pretreatment with CAPE-NO2 significantly ameliorated these changes, and decreased the infarct size, as compared with the IR control group (10.32±3.8 vs. 35.65±5.4%). Furthermore, western blotting demonstrated that pretreatment with CAPE-NO2 downregulated the myocardial IR-induced protein expression levels of B-cell lymphoma-2 (Bcl-2)-associated X protein (Bax), cleaved caspase-3, P38 and the Bax/Bcl-2 ratio. CAPE-NO2 also upregulated the myocardial IR-induced expression levels of Bcl-2, phosphoinositide-3-kinase, phosphorylated Akt and mammalian target of rapamycin. In conclusion, the results of the present study indicated that CAPE-NO2 demonstrated improved cardioprotective effects, as compared with CAPE; therefore, CAPE-NO2 may represent a novel approach to pharmacological cardioprotection." @default.
• W2268783256 created "2016-06-24" @default.
• W2268783256 creator A5021787883 @default.
• W2268783256 creator A5027250150 @default.
• W2268783256 creator A5030923616 @default.
• W2268783256 creator A5058188914 @default.
• W2268783256 creator A5063447635 @default.
• W2268783256 creator A5076145064 @default.
• W2268783256 creator A5084810313 @default.
• W2268783256 date "2016-02-10" @default.
• W2268783256 modified "2023-09-27" @default.
• W2268783256 title "Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats" @default.
• W2268783256 cites W1965994212 @default.
• W2268783256 cites W1995061819 @default.
• W2268783256 cites W2020861617 @default.
• W2268783256 cites W2039488599 @default.
• W2268783256 cites W2053134226 @default.
• W2268783256 cites W2058304611 @default.
• W2268783256 cites W2059571803 @default.
• W2268783256 cites W2061001947 @default.
• W2268783256 cites W2070118415 @default.
• W2268783256 cites W2072070639 @default.
• W2268783256 cites W2073233153 @default.
• W2268783256 cites W2074974255 @default.
• W2268783256 cites W2076415786 @default.
• W2268783256 cites W2085113952 @default.
• W2268783256 cites W2093878912 @default.
• W2268783256 cites W2118909000 @default.
• W2268783256 cites W2133022503 @default.
• W2268783256 cites W2284332287 @default.
• W2268783256 doi "https://doi.org/10.3892/etm.2016.3070" @default.
• W2268783256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4812399" @default.
• W2268783256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27073461" @default.
• W2268783256 hasPublicationYear "2016" @default.
• W2268783256 type Work @default.
• W2268783256 sameAs 2268783256 @default.
• W2268783256 citedByCount "20" @default.
• W2268783256 countsByYear W22687832562016 @default.
• W2268783256 countsByYear W22687832562017 @default.
• W2268783256 countsByYear W22687832562018 @default.
• W2268783256 countsByYear W22687832562019 @default.
• W2268783256 countsByYear W22687832562020 @default.
• W2268783256 countsByYear W22687832562021 @default.
• W2268783256 countsByYear W22687832562022 @default.
• W2268783256 crossrefType "journal-article" @default.
• W2268783256 hasAuthorship W2268783256A5021787883 @default.
• W2268783256 hasAuthorship W2268783256A5027250150 @default.
• W2268783256 hasAuthorship W2268783256A5030923616 @default.
• W2268783256 hasAuthorship W2268783256A5058188914 @default.
• W2268783256 hasAuthorship W2268783256A5063447635 @default.
• W2268783256 hasAuthorship W2268783256A5076145064 @default.
• W2268783256 hasAuthorship W2268783256A5084810313 @default.
• W2268783256 hasBestOaLocation W22687832561 @default.
• W2268783256 hasConcept C126322002 @default.
• W2268783256 hasConcept C134018914 @default.
• W2268783256 hasConcept C160160445 @default.
• W2268783256 hasConcept C181199279 @default.
• W2268783256 hasConcept C185592680 @default.
• W2268783256 hasConcept C190283241 @default.
• W2268783256 hasConcept C2775838275 @default.
• W2268783256 hasConcept C2776151105 @default.
• W2268783256 hasConcept C2776992468 @default.
• W2268783256 hasConcept C2777318727 @default.
• W2268783256 hasConcept C2778004101 @default.
• W2268783256 hasConcept C2778224086 @default.
• W2268783256 hasConcept C2778760513 @default.
• W2268783256 hasConcept C2779679107 @default.
• W2268783256 hasConcept C2780114680 @default.
• W2268783256 hasConcept C2780829032 @default.
• W2268783256 hasConcept C36880943 @default.
• W2268783256 hasConcept C541997718 @default.
• W2268783256 hasConcept C55493867 @default.
• W2268783256 hasConcept C71924100 @default.
• W2268783256 hasConcept C75217442 @default.
• W2268783256 hasConcept C98274493 @default.
• W2268783256 hasConceptScore W2268783256C126322002 @default.
• W2268783256 hasConceptScore W2268783256C134018914 @default.
• W2268783256 hasConceptScore W2268783256C160160445 @default.
• W2268783256 hasConceptScore W2268783256C181199279 @default.
• W2268783256 hasConceptScore W2268783256C185592680 @default.
• W2268783256 hasConceptScore W2268783256C190283241 @default.
• W2268783256 hasConceptScore W2268783256C2775838275 @default.
• W2268783256 hasConceptScore W2268783256C2776151105 @default.
• W2268783256 hasConceptScore W2268783256C2776992468 @default.
• W2268783256 hasConceptScore W2268783256C2777318727 @default.
• W2268783256 hasConceptScore W2268783256C2778004101 @default.
• W2268783256 hasConceptScore W2268783256C2778224086 @default.
• W2268783256 hasConceptScore W2268783256C2778760513 @default.
• W2268783256 hasConceptScore W2268783256C2779679107 @default.
• W2268783256 hasConceptScore W2268783256C2780114680 @default.
• W2268783256 hasConceptScore W2268783256C2780829032 @default.
• W2268783256 hasConceptScore W2268783256C36880943 @default.
• W2268783256 hasConceptScore W2268783256C541997718 @default.
• W2268783256 hasConceptScore W2268783256C55493867 @default.
• W2268783256 hasConceptScore W2268783256C71924100 @default.
• W2268783256 hasConceptScore W2268783256C75217442 @default.
• W2268783256 hasConceptScore W2268783256C98274493 @default.
• W2268783256 hasIssue "4" @default.

• next