Matches in SemOpenAlex for { <https://semopenalex.org/work/W2268846719> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2268846719 abstract "Previously, we showed that AR deficiency prevents retinal abnormalities in 15 mos. diabetic db/db mice. Here, we explored the role of AR in ischemic retinal injury, since the retinal damage associated with diabetes is thought to be the consequence of ischemia. To induce retinal ischemia, we blocked the ophthalmic artery, which gives rise to central retinal artery, by using 2 hrs of internal carotid artery occlusion and 22 hrs of reperfusion by intraluminal insertion of filament. Here, we compared the ipsilateral retina of 8 wks old AR-wild type (AR+/+) to the similar aged AR−/− mice after transient ischemia. After the transient ischemia, there was a significant increase of total retinal thickness and neuronal cell loss in the ipsilateral side of AR+/+ retinas, but not of the AR−/− retinas when compared with the contralateral sides, respectively. Increase of neuro-retinal damage after the transient ischemia triggered the increased expression of glutamine synthetase, which was shown to protect against neuronal degeneration in injured retinal tissues, and markers of glial reactivation, such as glial acidic fibrillary protein (GFAP) and S-100 in Müller cells in the ipsilateral side of AR+/+, but not of the AR−/− retinas, when compared with the contralateral sides, respectively. This suggests that AR deficiency prevents neuro-retinal damage and glial reactivation induced by the carotid artery transient ischemia. This research was supported by Research Grants Council of Hong Kong Grant to Dr. S.K. Chung." @default.
- W2268846719 created "2016-06-24" @default.
- W2268846719 creator A5040802828 @default.
- W2268846719 creator A5049727518 @default.
- W2268846719 creator A5066420309 @default.
- W2268846719 creator A5072420464 @default.
- W2268846719 date "2006-03-01" @default.
- W2268846719 modified "2023-10-01" @default.
- W2268846719 title "Aldose reductase‐deficient mice were protected from the neuro‐retinal injury after carotid artery transient ischemia" @default.
- W2268846719 doi "https://doi.org/10.1096/fasebj.20.4.a639-d" @default.
- W2268846719 hasPublicationYear "2006" @default.
- W2268846719 type Work @default.
- W2268846719 sameAs 2268846719 @default.
- W2268846719 citedByCount "0" @default.
- W2268846719 crossrefType "journal-article" @default.
- W2268846719 hasAuthorship W2268846719A5040802828 @default.
- W2268846719 hasAuthorship W2268846719A5049727518 @default.
- W2268846719 hasAuthorship W2268846719A5066420309 @default.
- W2268846719 hasAuthorship W2268846719A5072420464 @default.
- W2268846719 hasConcept C118487528 @default.
- W2268846719 hasConcept C126322002 @default.
- W2268846719 hasConcept C134018914 @default.
- W2268846719 hasConcept C169760540 @default.
- W2268846719 hasConcept C204232928 @default.
- W2268846719 hasConcept C2777093970 @default.
- W2268846719 hasConcept C2780495277 @default.
- W2268846719 hasConcept C2780827179 @default.
- W2268846719 hasConcept C541997718 @default.
- W2268846719 hasConcept C71924100 @default.
- W2268846719 hasConcept C86803240 @default.
- W2268846719 hasConceptScore W2268846719C118487528 @default.
- W2268846719 hasConceptScore W2268846719C126322002 @default.
- W2268846719 hasConceptScore W2268846719C134018914 @default.
- W2268846719 hasConceptScore W2268846719C169760540 @default.
- W2268846719 hasConceptScore W2268846719C204232928 @default.
- W2268846719 hasConceptScore W2268846719C2777093970 @default.
- W2268846719 hasConceptScore W2268846719C2780495277 @default.
- W2268846719 hasConceptScore W2268846719C2780827179 @default.
- W2268846719 hasConceptScore W2268846719C541997718 @default.
- W2268846719 hasConceptScore W2268846719C71924100 @default.
- W2268846719 hasConceptScore W2268846719C86803240 @default.
- W2268846719 hasIssue "4" @default.
- W2268846719 hasLocation W22688467191 @default.
- W2268846719 hasOpenAccess W2268846719 @default.
- W2268846719 hasPrimaryLocation W22688467191 @default.
- W2268846719 hasRelatedWork W1898485904 @default.
- W2268846719 hasRelatedWork W1988518318 @default.
- W2268846719 hasRelatedWork W1995133512 @default.
- W2268846719 hasRelatedWork W2000823655 @default.
- W2268846719 hasRelatedWork W2090484837 @default.
- W2268846719 hasRelatedWork W2160704957 @default.
- W2268846719 hasRelatedWork W2383432903 @default.
- W2268846719 hasRelatedWork W2535689908 @default.
- W2268846719 hasRelatedWork W3172361014 @default.
- W2268846719 hasRelatedWork W4290994103 @default.
- W2268846719 hasVolume "20" @default.
- W2268846719 isParatext "false" @default.
- W2268846719 isRetracted "false" @default.
- W2268846719 magId "2268846719" @default.
- W2268846719 workType "article" @default.