Matches in SemOpenAlex for { <https://semopenalex.org/work/W2268869884> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2268869884 abstract "The frequency and distribution of genetic polymorphism in the human genome is a question of major importance. We have studied this in highly conserved genes, which encode crucial functions such as DNA replication, mRNA transcription, and translation. Evolutionary comparisons suggest that these genes are under particularly strong selective pressure, and their frequency of nucleotide sequence polymorphism would be expected to represent a minimum estimate for sequence variation throughout the genome. We have analyzed the complete coding sequence and the 3'-untranslated region (3'-UTR) of 22 human genes, most of which have homologs in all cellular organisms and all of which are at least 25% amino acid identical to homologs in yeast. Comparisons with similar studies of less conserved human disease genes indicate that 1) evolutionarily conserved genes are, on average, less polymorphic than disease related genes; 2) the difference in polymorphism levels is attributable almost entirely to reduced levels of variation in protein coding sequences, whereas noncoding sequences have similar levels of polymorphism; and 3) the character of polymorphism, in terms of the spectrum and frequency of mutational changes, is similar." @default.
- W2268869884 created "2016-06-24" @default.
- W2268869884 creator A5016442374 @default.
- W2268869884 creator A5020136146 @default.
- W2268869884 creator A5032625076 @default.
- W2268869884 creator A5041211667 @default.
- W2268869884 creator A5059837487 @default.
- W2268869884 date "2001-04-02" @default.
- W2268869884 modified "2023-09-26" @default.
- W2268869884 title "Genetic variation in mRNA coding sequences of highly conserved genes" @default.
- W2268869884 cites W1711580613 @default.
- W2268869884 cites W1970363166 @default.
- W2268869884 cites W1978920258 @default.
- W2268869884 cites W1990739064 @default.
- W2268869884 cites W1992788548 @default.
- W2268869884 cites W2041652393 @default.
- W2268869884 cites W2042103448 @default.
- W2268869884 cites W2052952227 @default.
- W2268869884 cites W2053096433 @default.
- W2268869884 cites W2066614521 @default.
- W2268869884 cites W2069445267 @default.
- W2268869884 cites W2074754379 @default.
- W2268869884 cites W2079501979 @default.
- W2268869884 cites W2087656850 @default.
- W2268869884 cites W2119923823 @default.
- W2268869884 cites W2121016876 @default.
- W2268869884 cites W2160782760 @default.
- W2268869884 cites W4254753097 @default.
- W2268869884 doi "https://doi.org/10.1152/physiolgenomics.2001.5.3.113" @default.
- W2268869884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11285364" @default.
- W2268869884 hasPublicationYear "2001" @default.
- W2268869884 type Work @default.
- W2268869884 sameAs 2268869884 @default.
- W2268869884 citedByCount "18" @default.
- W2268869884 countsByYear W22688698842012 @default.
- W2268869884 countsByYear W22688698842013 @default.
- W2268869884 crossrefType "journal-article" @default.
- W2268869884 hasAuthorship W2268869884A5016442374 @default.
- W2268869884 hasAuthorship W2268869884A5020136146 @default.
- W2268869884 hasAuthorship W2268869884A5032625076 @default.
- W2268869884 hasAuthorship W2268869884A5041211667 @default.
- W2268869884 hasAuthorship W2268869884A5059837487 @default.
- W2268869884 hasConcept C104317684 @default.
- W2268869884 hasConcept C141231307 @default.
- W2268869884 hasConcept C197077220 @default.
- W2268869884 hasConcept C199216141 @default.
- W2268869884 hasConcept C3017666073 @default.
- W2268869884 hasConcept C54355233 @default.
- W2268869884 hasConcept C66746571 @default.
- W2268869884 hasConcept C68873052 @default.
- W2268869884 hasConcept C70721500 @default.
- W2268869884 hasConcept C78458016 @default.
- W2268869884 hasConcept C86803240 @default.
- W2268869884 hasConcept C91779695 @default.
- W2268869884 hasConceptScore W2268869884C104317684 @default.
- W2268869884 hasConceptScore W2268869884C141231307 @default.
- W2268869884 hasConceptScore W2268869884C197077220 @default.
- W2268869884 hasConceptScore W2268869884C199216141 @default.
- W2268869884 hasConceptScore W2268869884C3017666073 @default.
- W2268869884 hasConceptScore W2268869884C54355233 @default.
- W2268869884 hasConceptScore W2268869884C66746571 @default.
- W2268869884 hasConceptScore W2268869884C68873052 @default.
- W2268869884 hasConceptScore W2268869884C70721500 @default.
- W2268869884 hasConceptScore W2268869884C78458016 @default.
- W2268869884 hasConceptScore W2268869884C86803240 @default.
- W2268869884 hasConceptScore W2268869884C91779695 @default.
- W2268869884 hasLocation W22688698841 @default.
- W2268869884 hasLocation W22688698842 @default.
- W2268869884 hasOpenAccess W2268869884 @default.
- W2268869884 hasPrimaryLocation W22688698841 @default.
- W2268869884 hasRelatedWork W1544851750 @default.
- W2268869884 hasRelatedWork W1966882987 @default.
- W2268869884 hasRelatedWork W1993464731 @default.
- W2268869884 hasRelatedWork W2048655539 @default.
- W2268869884 hasRelatedWork W2050813649 @default.
- W2268869884 hasRelatedWork W2076210386 @default.
- W2268869884 hasRelatedWork W2102082319 @default.
- W2268869884 hasRelatedWork W2111427849 @default.
- W2268869884 hasRelatedWork W2114611642 @default.
- W2268869884 hasRelatedWork W2160357604 @default.
- W2268869884 hasRelatedWork W2162474401 @default.
- W2268869884 hasRelatedWork W2163310679 @default.
- W2268869884 hasRelatedWork W2168665035 @default.
- W2268869884 hasRelatedWork W2183262987 @default.
- W2268869884 hasRelatedWork W2266103947 @default.
- W2268869884 hasRelatedWork W2337476676 @default.
- W2268869884 hasRelatedWork W273051960 @default.
- W2268869884 hasRelatedWork W3142010254 @default.
- W2268869884 hasRelatedWork W3158023970 @default.
- W2268869884 hasRelatedWork W43318502 @default.
- W2268869884 isParatext "false" @default.
- W2268869884 isRetracted "false" @default.
- W2268869884 magId "2268869884" @default.
- W2268869884 workType "article" @default.