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- W2268872739 abstract "Advanced oxidation processes are promising technologies for removal of antibiotic residues from wastewater in terms of their high efficacy. However, recent studies have reported the remaining antibacterial activity of the products at early-stages of treatment. The present study investigates the effect of such products of model β-lactams (amoxicillin, ampicillin, cloxacillin) on bacteria introducing structure-based, and biological approaches involving Gram-positive and Gram-negative bacterial strains. Chemical analysis revealed the destruction of the β-lactam pharmacophore in competition with the reaction at the aromatic ring. Multisite attack occurs on the penicillin skeleton producing OH-substituted products. The enhanced hydrophilicity confers higher diffusion rate through the porin channels of Gram-negative bacteria and through the hydrophilic cell wall of Gram-positive species. Accordingly, an increase in acute toxicity of treated samples was observed at the beginning of the treatment. The same tendency was observed for target-specific antimicrobial activity investigated with antibiotic susceptibility testing (agar-diffusion, bacterial growth). Prolonged treatments yielded products, e.g. polyhydroxylated phenolic compounds, being also deleterious for bacteria. Therefore, the advanced oxidation process should be judiciously optimized." @default.
- W2268872739 created "2016-06-24" @default.
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- W2268872739 date "2016-05-01" @default.
- W2268872739 modified "2023-09-27" @default.
- W2268872739 title "Change in hydrophilicity of penicillins during advanced oxidation by radiolytically generated OH compromises the elimination of selective pressure on bacterial strains" @default.
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- W2268872739 doi "https://doi.org/10.1016/j.scitotenv.2016.02.002" @default.
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