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- W2268996845 abstract "The structures of epitopes bound by autoantibodies against RNA-protein complexes have been well-defined over several decades, but little is known of the clonality, immunoglobulin (Ig) variable (V) gene usage and mutational status of the autoantibodies themselves at the level of the secreted (serum) proteome. A novel proteomic workflow is presented based on affinity purification of specific Igs from serum, high-resolution two-dimensional gel electrophoresis, and de novo and database-driven sequencing of V-region proteins by mass spectrometry. Analysis of anti-Ro52/Ro60/La proteomes in primary Sjögren's syndrome (SS) and anti-Sm and anti-ribosomal P proteomes in systemic lupus erythematosus (SLE) has revealed that these antibody responses are dominated by restricted sets of public (shared) clonotypes, consistent with common pathways of production across unrelated individuals. The discovery of shared sets of specific V-region peptides can be exploited for diagnostic biomarkers in targeted mass spectrometry platforms and for tracking and removal of pathogenic clones." @default.
- W2268996845 created "2016-06-24" @default.
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- W2268996845 date "2016-04-01" @default.
- W2268996845 modified "2023-09-27" @default.
- W2268996845 title "Secreted autoantibody repertoires in Sjögren's syndrome and systemic lupus erythematosus: A proteomic approach" @default.
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- W2268996845 cites W1533699036 @default.
- W2268996845 cites W1534828473 @default.
- W2268996845 cites W1550723234 @default.
- W2268996845 cites W1552738427 @default.
- W2268996845 cites W1555071558 @default.
- W2268996845 cites W1810734999 @default.
- W2268996845 cites W1965989630 @default.
- W2268996845 cites W1968044517 @default.
- W2268996845 cites W1974963484 @default.
- W2268996845 cites W1978280209 @default.
- W2268996845 cites W1985637111 @default.
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- W2268996845 cites W1993577127 @default.
- W2268996845 cites W1993928780 @default.
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- W2268996845 cites W2000802347 @default.
- W2268996845 cites W2004636952 @default.
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- W2268996845 cites W2013680809 @default.
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- W2268996845 cites W2023909701 @default.
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- W2268996845 doi "https://doi.org/10.1016/j.autrev.2016.01.008" @default.
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