Matches in SemOpenAlex for { <https://semopenalex.org/work/W2269030568> ?p ?o ?g. }
- W2269030568 endingPage "25426" @default.
- W2269030568 startingPage "25411" @default.
- W2269030568 abstract "Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII) signaling in the heart regulates cardiomyocyte contractility and growth in response to elevated intracellular Ca(2+). The δB isoform of CaMKII is the predominant nuclear splice variant in the adult heart and regulates cardiomyocyte hypertrophic gene expression by signaling to the histone deacetylase HDAC4. However, the role of CaMKIIδ in cardiac progenitor cells (CPCs) has not been previously explored. During post-natal growth endogenous CPCs display primarily cytosolic CaMKIIδ, which localizes to the nuclear compartment of CPCs after myocardial infarction injury. CPCs undergoing early differentiation in vitro increase levels of CaMKIIδB in the nuclear compartment where the kinase may contribute to the regulation of CPC commitment. CPCs modified with lentiviral-based constructs to overexpress CaMKIIδB (CPCeδB) have reduced proliferative rate compared with CPCs expressing eGFP alone (CPCe). Additionally, stable expression of CaMKIIδB promotes distinct morphological changes such as increased cell surface area and length of cells compared with CPCe. CPCeδB are resistant to oxidative stress induced by hydrogen peroxide (H2O2) relative to CPCe, whereas knockdown of CaMKIIδB resulted in an up-regulation of cell death and cellular senescence markers compared with scrambled treated controls. Dexamethasone (Dex) treatment increased mRNA and protein expression of cardiomyogenic markers cardiac troponin T and α-smooth muscle actin in CPCeδB compared with CPCe, suggesting increased differentiation. Therefore, CaMKIIδB may serve as a novel modulatory protein to enhance CPC survival and commitment into the cardiac and smooth muscle lineages." @default.
- W2269030568 created "2016-06-24" @default.
- W2269030568 creator A5003393607 @default.
- W2269030568 creator A5019414228 @default.
- W2269030568 creator A5020824899 @default.
- W2269030568 creator A5021539064 @default.
- W2269030568 creator A5032978625 @default.
- W2269030568 creator A5052640009 @default.
- W2269030568 creator A5059234351 @default.
- W2269030568 creator A5067873023 @default.
- W2269030568 creator A5074558279 @default.
- W2269030568 creator A5088451122 @default.
- W2269030568 date "2015-10-01" @default.
- W2269030568 modified "2023-10-17" @default.
- W2269030568 title "Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment" @default.
- W2269030568 cites W1502059201 @default.
- W2269030568 cites W1521707994 @default.
- W2269030568 cites W1963840916 @default.
- W2269030568 cites W1971977081 @default.
- W2269030568 cites W1977437881 @default.
- W2269030568 cites W1978682827 @default.
- W2269030568 cites W1995536179 @default.
- W2269030568 cites W1997195556 @default.
- W2269030568 cites W2010368308 @default.
- W2269030568 cites W2011182719 @default.
- W2269030568 cites W2013668219 @default.
- W2269030568 cites W2016854124 @default.
- W2269030568 cites W2017944474 @default.
- W2269030568 cites W2021737405 @default.
- W2269030568 cites W2023793544 @default.
- W2269030568 cites W2024257303 @default.
- W2269030568 cites W2025804021 @default.
- W2269030568 cites W2034503181 @default.
- W2269030568 cites W2037250671 @default.
- W2269030568 cites W2038646880 @default.
- W2269030568 cites W2039916525 @default.
- W2269030568 cites W2044107405 @default.
- W2269030568 cites W2046027917 @default.
- W2269030568 cites W2046644745 @default.
- W2269030568 cites W2051572996 @default.
- W2269030568 cites W2053853042 @default.
- W2269030568 cites W2055323054 @default.
- W2269030568 cites W2059331322 @default.
- W2269030568 cites W2064781260 @default.
- W2269030568 cites W2067009965 @default.
- W2269030568 cites W2089643774 @default.
- W2269030568 cites W2102525690 @default.
- W2269030568 cites W2103807671 @default.
- W2269030568 cites W2113111385 @default.
- W2269030568 cites W2116855418 @default.
- W2269030568 cites W2116934212 @default.
- W2269030568 cites W2132735690 @default.
- W2269030568 cites W2133971379 @default.
- W2269030568 cites W2135241125 @default.
- W2269030568 cites W2143826295 @default.
- W2269030568 cites W2145362275 @default.
- W2269030568 cites W2150652185 @default.
- W2269030568 cites W2153899938 @default.
- W2269030568 cites W2159995809 @default.
- W2269030568 cites W2160092129 @default.
- W2269030568 cites W2161304727 @default.
- W2269030568 cites W2165104370 @default.
- W2269030568 cites W2170297351 @default.
- W2269030568 doi "https://doi.org/10.1074/jbc.m115.657775" @default.
- W2269030568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4646189" @default.
- W2269030568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26324717" @default.
- W2269030568 hasPublicationYear "2015" @default.
- W2269030568 type Work @default.
- W2269030568 sameAs 2269030568 @default.
- W2269030568 citedByCount "17" @default.
- W2269030568 countsByYear W22690305682016 @default.
- W2269030568 countsByYear W22690305682017 @default.
- W2269030568 countsByYear W22690305682018 @default.
- W2269030568 countsByYear W22690305682019 @default.
- W2269030568 countsByYear W22690305682021 @default.
- W2269030568 crossrefType "journal-article" @default.
- W2269030568 hasAuthorship W2269030568A5003393607 @default.
- W2269030568 hasAuthorship W2269030568A5019414228 @default.
- W2269030568 hasAuthorship W2269030568A5020824899 @default.
- W2269030568 hasAuthorship W2269030568A5021539064 @default.
- W2269030568 hasAuthorship W2269030568A5032978625 @default.
- W2269030568 hasAuthorship W2269030568A5052640009 @default.
- W2269030568 hasAuthorship W2269030568A5059234351 @default.
- W2269030568 hasAuthorship W2269030568A5067873023 @default.
- W2269030568 hasAuthorship W2269030568A5074558279 @default.
- W2269030568 hasAuthorship W2269030568A5088451122 @default.
- W2269030568 hasBestOaLocation W22690305681 @default.
- W2269030568 hasConcept C181080969 @default.
- W2269030568 hasConcept C184235292 @default.
- W2269030568 hasConcept C185592680 @default.
- W2269030568 hasConcept C201750760 @default.
- W2269030568 hasConcept C207200792 @default.
- W2269030568 hasConcept C28328180 @default.
- W2269030568 hasConcept C79879829 @default.
- W2269030568 hasConcept C86803240 @default.
- W2269030568 hasConcept C95444343 @default.
- W2269030568 hasConcept C97029542 @default.
- W2269030568 hasConceptScore W2269030568C181080969 @default.