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- W2269105636 abstract "The aim of this study was to determine whether overweight/obese adults with abdominal adiposity exhibit greater oxidative stress and inflammatory burden compared with overweight/obese adults without abdominal obesity. 38 sedentary, adult males free of cardiometabolic disease were studied: 12 normal weight (age 54±2 yr; BMI 22.4±0.6 kg/m2; waist circumference [WC] 82.9+1.4 cm); 15 overweight/obese with WC <102 cm (58+2 yr; 28.1+0.3 kg/m2; 95.5+0.8 cm); and 11 overweight/obese with WC >102 cm (58+3 yr; 29.8+0.7 kg/m2; 107.9+1.7 cm). Plasma concentrations of oxidized low-density lipoprotein (ox-LDL), C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-18 were determined by ELISA. Plasma oxLDL (48.7±2.3 U/L), CRP (0.4±0.1 mg/L), TNF-α (1.5±0.1 pg/mL), IL-6 (1.3±0.2 pg/mL) and IL-18 (214±12 pg/mL) levels were lowest in normal weight controls. Importantly, overweight/obese men with abdominal adiposity had significantly higher CRP (2.5±0.7 vs 1.1±0.2 mg/L), IL-6 (2.9±0.7 vs 1.5±0.3 pg/mL) and IL-18 (292±15 vs 228±16 pg/mL) levels than overweight/obese adults without abdominal adiposity. There were no group differences in either ox-LDL (58.4±7.5 vs 55.0±6.0 U/L) or TNF-α (2.1±0.2 vs 2.6±0.6 pg/mL) amongst the overweight/obese men. These results suggest that abdominal obesity is associated with a more unfavorable inflammatory phenotype in overweight/obese men." @default.
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- W2269105636 date "2014-04-01" @default.
- W2269105636 modified "2023-09-26" @default.
- W2269105636 title "Influence of abdominal obesity on circulating oxidative and inflammatory markers in overweight/obese adult men (1107.7)" @default.
- W2269105636 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1107.7" @default.
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