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• W2269245890 abstract "Specie A Rotaviruses (RVA) are responsible for acute gastroenteritis (GA) in many animal species. In humans, children under five years old are the most affected. Each year, about453,000 infant deaths are causedbyRV infections. Due to this public health impact, prevention and control measures were established: in March 2006, the Brazilian Health Ministry made available an monovalent attenuated vaccine, called Rotarix®. According to World Health Organization, extensive and continuous monitoring of RVA strains and surveillance studies are necessary to evaluate the impact and efficacy vaccine and to investigate appearance of new viral variants that could possibly escape the immunization procedure. For a better characterization and understanding of the RVA genetic diversity, proposed a new classification system encompassing all 11 RVA gene segments. This approach has facilitated the exponential growth of complete RVA genome data during recent years. On the basis of complete RVA genome sequence comparisons, two major genotype constellations (genogroups): I1-R1-C1-M1-A1-N1-T1-E1-H1 (Wa-like) and I2-R2-C2-M2-A2-N2-T2-E2-H2 (DS1-like), have been shown to circulate worldwide among humans. A third (minor) human genotype constellation, referred to as AU1-like (I3-R3-C3-M3-A3-N3-T3-E3-H3).In Brazil, studiesinvolving the characterization of all genes segments are rare. In the current study, a total of40 fecal specimens were selected between 1994 and 2011 from children hospitalized due to acute diarrhea caused by RVA G1, G2, G3, G4, G9 and G12 in Northern Brazil region, aiming to evaluate the RVA genetic diversity in the pre-vaccine period and post-vaccine.For this, the RVA genes were amplified, the amplicons were sequenced and analyzed for phylogenetic reconstruction. Based this analysis were identified threesubgenotype alleles for each gene, allowing evidence conserved genotypic constellations, though related to three distinct genogroups: Wa-like, DS1-like e AU-like. AU1-like strain(PID084) revealed close relationship with genes feline origin. The results also show evidence some genetic variability mechanisms: inergenogroup reassortments events occourring between human-human and human-animal genes ; intragenogroup reassortment events in G1P[8], G2P[4], G3P[8], G4P[6], G4P[8] RVAstrains between human-human and human-animal gene, newly; and still occurring point mutations in the sequences of all genes of strains analyzed. Alarge degree of variability has been found in circulating strains before vaccine introduction.Regarding genes encoding foreign proteins, it was possible to identify changes in residues located in antigenic regions and may reflect significant changes in structural proteins.In conclusion, the current work help to increase the knowledge on the genomic diversity of RVA, aiming detect new variants and possible antigenic changes, whose potential effect on vaccine effectiveness should be studied. Additionally, our findings identified close relationships between human and animal RVA, contribute to clarify characteristics that can pose a challenge for the Brazilian National Immunization Program" @default.
• W2269245890 created "2016-06-24" @default.
• W2269245890 creator A5061603912 @default.
• W2269245890 date "2013-01-01" @default.
• W2269245890 modified "2023-09-23" @default.
• W2269245890 title "Análise filogenética dos genes que codificam para proteínas estruturais e não estruturais de rotavírus a detectados na região norte do Brasil, antes e após a introdução da vacina Rotarix®" @default.
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