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- W2269434983 abstract "T lymphocytes recognize antigens in the form of short peptides presented by MHC molecules. Although MHC-restricted antigen presentation is an essential process for the initiation T cell responses, it has received little attention as a target of therapeutic immunomodulation. In an effort to search for and characterize MHC-restricted antigen presentation modulators, we screened several thousands of compounds for their ability to inhibit or enhance exogenous antigen presentation in dendritic cells (DCs). We found that COX-1 inhibitors, aspirin and ibuprofen, efficiently block MHC-restricted presentation of an exogenous antigen, ovalbumin (OVA), when added to cultures of DC2.4 cells and BM-DCs for 18 h or longer. The antigen presentation inhibitory activity of ibuprofen was much more potent than aspirin. The COX-1 inhibitors, however, did not affect phagocytic activity, the expression level of total MHC molecules and co-stimulatory molecules in DCs. DCs differentiated from BM cells in the presence of COX-1 inhibitors were also suppressed in the antigen presentation capability, and this suppressive activity was more prominent when developing DCs were exposed with the COX-1 inhibitors at the early stage of maturation. These results suggest that prolonged administration of COX-1 inhibitors may impair antigen presentation capability of DCs." @default.
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- W2269434983 date "2008-03-01" @default.
- W2269434983 modified "2023-09-23" @default.
- W2269434983 title "COX‐1 inhibitors block MHC‐restricted exogenous antigen presentation in dendritic cells" @default.
- W2269434983 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1067.8" @default.
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