FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2269519750> ?p ?o ?g. }

• W2269519750 abstract "Introduction and objectives. Measures of adiposity such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with adverse cardiovascular events and diabetes independent of body mass index (BMI). WC and WHR have high heritability and multiple susceptibility loci have been identified across the genome, including GRB14 , LYPAL1 , and VEGFA . We aim to identify novel loci associated with WC and WHR using a bespoke SNP array focused on cardio-centric candidate genes. Methods. We assessed the association between SNPs and anthropometry phenotypes WC adjusted for BMI (cm), and WHR adjusted for BMI among 51990 individuals of European ancestry from NHLBI’s Candidate Gene Association Resource (CARe) project and 14 other cohorts. The study population consisted of women and men aged 20 to 80, of which 65% were females. Individuals were genotyped using the ITMAT/Broad/CARE (IBC) chip, which includes ∼50,000 densely mapped cosmopolitan tagged SNPs across ∼2100 candidate genes. We modeled each trait as a function of age, study site, and ancestry, and conducted a fixed-effects meta-analysis. Results. Three novel loci reached our Bonferroni adjusted threshold for statistical significance (P<2E-6). The A allele of SNP rs761422 in gene MFAP2 was associated with decreased WC adjusted for BMI (P=4.4E-7), and has previously been reported in a height GWAS. The C allele of SNP rs2811337 near TMCC1 , involved in signaling pathways, and the A allele of SNP rs7302703 in gene HOXC10 , involved in cell differentiation, were associated with decreased WHR adjusted for BMI (P=8.6E-9 and P=2.8E-7, respectively). Fourteen loci have been previously reported in association with WHR adjusted for BMI, five of which, were included on the IBC chip. Of the five, three also reached statistical significance with the same direction of effect in our sample: RSPO3 (P=3.0E-10), ADAMTS9 (P=8.6E-9),and ITPR2 (P=5.6E-8). All SNPs were common variants (MAF>10%). Fine mapping is currently underway to determine whether each locus may contain multiple independent signals. Replication cohorts have been identified and we are working to verify the novel loci and investigate sub-significant loci. Conclusions . In 51990 European decent individuals typed on a dense IBC chip, we identified 3 novel loci and replicated 3 additional loci. Significant loci among WC adjusted for BMI, and WHR adjusted for BMI were distinct from one another, indicating each measure of adiposity may be capturing distinct underlying phenotypes and thus different pathways through which risk alleles affect adiposity. We will pursue further assessment of risk loci and adiposity through fine mapping and follow-up genotyping." @default.
• W2269519750 created "2016-06-24" @default.
• W2269519750 creator A5003465102 @default.
• W2269519750 creator A5003546938 @default.
• W2269519750 creator A5006658658 @default.
• W2269519750 creator A5012110797 @default.
• W2269519750 creator A5014691736 @default.
• W2269519750 creator A5016286778 @default.
• W2269519750 creator A5018093575 @default.
• W2269519750 creator A5019339181 @default.
• W2269519750 creator A5031967231 @default.
• W2269519750 creator A5036551563 @default.
• W2269519750 creator A5036589831 @default.
• W2269519750 creator A5047140394 @default.
• W2269519750 creator A5050330450 @default.
• W2269519750 creator A5056798958 @default.
• W2269519750 creator A5057944271 @default.
• W2269519750 creator A5058430815 @default.
• W2269519750 creator A5062296084 @default.
• W2269519750 creator A5072564819 @default.
• W2269519750 creator A5075195377 @default.
• W2269519750 creator A5078482348 @default.
• W2269519750 creator A5079207212 @default.
• W2269519750 creator A5082464365 @default.
• W2269519750 creator A5083365578 @default.
• W2269519750 creator A5086342066 @default.
• W2269519750 date "2012-03-13" @default.
• W2269519750 modified "2023-09-26" @default.
• W2269519750 title "Abstract MP068: Association Study of SNPs and measures of adiposity among 51990 European and European American Identifies Three Novel Loci" @default.
• W2269519750 doi "https://doi.org/10.1161/circ.125.suppl_10.amp068" @default.
• W2269519750 hasPublicationYear "2012" @default.
• W2269519750 type Work @default.
• W2269519750 sameAs 2269519750 @default.
• W2269519750 citedByCount "0" @default.
• W2269519750 crossrefType "journal-article" @default.
• W2269519750 hasAuthorship W2269519750A5003465102 @default.
• W2269519750 hasAuthorship W2269519750A5003546938 @default.
• W2269519750 hasAuthorship W2269519750A5006658658 @default.
• W2269519750 hasAuthorship W2269519750A5012110797 @default.
• W2269519750 hasAuthorship W2269519750A5014691736 @default.
• W2269519750 hasAuthorship W2269519750A5016286778 @default.
• W2269519750 hasAuthorship W2269519750A5018093575 @default.
• W2269519750 hasAuthorship W2269519750A5019339181 @default.
• W2269519750 hasAuthorship W2269519750A5031967231 @default.
• W2269519750 hasAuthorship W2269519750A5036551563 @default.
• W2269519750 hasAuthorship W2269519750A5036589831 @default.
• W2269519750 hasAuthorship W2269519750A5047140394 @default.
• W2269519750 hasAuthorship W2269519750A5050330450 @default.
• W2269519750 hasAuthorship W2269519750A5056798958 @default.
• W2269519750 hasAuthorship W2269519750A5057944271 @default.
• W2269519750 hasAuthorship W2269519750A5058430815 @default.
• W2269519750 hasAuthorship W2269519750A5062296084 @default.
• W2269519750 hasAuthorship W2269519750A5072564819 @default.
• W2269519750 hasAuthorship W2269519750A5075195377 @default.
• W2269519750 hasAuthorship W2269519750A5078482348 @default.
• W2269519750 hasAuthorship W2269519750A5079207212 @default.
• W2269519750 hasAuthorship W2269519750A5082464365 @default.
• W2269519750 hasAuthorship W2269519750A5083365578 @default.
• W2269519750 hasAuthorship W2269519750A5086342066 @default.
• W2269519750 hasConcept C104317684 @default.
• W2269519750 hasConcept C106208931 @default.
• W2269519750 hasConcept C126322002 @default.
• W2269519750 hasConcept C135763542 @default.
• W2269519750 hasConcept C139275648 @default.
• W2269519750 hasConcept C153209595 @default.
• W2269519750 hasConcept C157410074 @default.
• W2269519750 hasConcept C186413461 @default.
• W2269519750 hasConcept C2776193436 @default.
• W2269519750 hasConcept C2780221984 @default.
• W2269519750 hasConcept C2908647359 @default.
• W2269519750 hasConcept C33997684 @default.
• W2269519750 hasConcept C35605836 @default.
• W2269519750 hasConcept C54355233 @default.
• W2269519750 hasConcept C69991583 @default.
• W2269519750 hasConcept C71924100 @default.
• W2269519750 hasConcept C86803240 @default.
• W2269519750 hasConcept C99454951 @default.
• W2269519750 hasConceptScore W2269519750C104317684 @default.
• W2269519750 hasConceptScore W2269519750C106208931 @default.
• W2269519750 hasConceptScore W2269519750C126322002 @default.
• W2269519750 hasConceptScore W2269519750C135763542 @default.
• W2269519750 hasConceptScore W2269519750C139275648 @default.
• W2269519750 hasConceptScore W2269519750C153209595 @default.
• W2269519750 hasConceptScore W2269519750C157410074 @default.
• W2269519750 hasConceptScore W2269519750C186413461 @default.
• W2269519750 hasConceptScore W2269519750C2776193436 @default.
• W2269519750 hasConceptScore W2269519750C2780221984 @default.
• W2269519750 hasConceptScore W2269519750C2908647359 @default.
• W2269519750 hasConceptScore W2269519750C33997684 @default.
• W2269519750 hasConceptScore W2269519750C35605836 @default.
• W2269519750 hasConceptScore W2269519750C54355233 @default.
• W2269519750 hasConceptScore W2269519750C69991583 @default.
• W2269519750 hasConceptScore W2269519750C71924100 @default.
• W2269519750 hasConceptScore W2269519750C86803240 @default.
• W2269519750 hasConceptScore W2269519750C99454951 @default.
• W2269519750 hasIssue "suppl_10" @default.
• W2269519750 hasLocation W22695197501 @default.
• W2269519750 hasOpenAccess W2269519750 @default.
• W2269519750 hasPrimaryLocation W22695197501 @default.
• W2269519750 hasRelatedWork W1633169450 @default.

• next